ONECUT2 Activates Diverse Resistance Drivers of Androgen Receptor-Independent Heterogeneity in Prostate Cancer

Androgen receptor- (AR-) indifference is a mechanism of resistance to hormonal therapy in prostate cancer (PC). Here we demonstrate that the HOX/CUT transcription factor ONECUT2 (OC2) activates resistance through multiple drivers associated with adenocarcinoma, stem-like and neuroendocrine (NE) vari...

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Detalles Bibliográficos
Autores principales: Qian, Chen, Yang, Qian, Rotinen, Mirja, Huang, Rongrong, Kim, Hyoyoung, Gallent, Brad, Yan, Yiwu, Cadaneanu, Radu M., Zhang, Baohui, Kaochar, Salma, Freedland, Stephen J., Posadas, Edwin M., Ellis, Leigh, Vizio, Dolores Di, Morrissey, Colm, Nelson, Peter S., Brady, Lauren, Murali, Ramachandran, Campbell, Moray J., Yang, Wei, Knudsen, Beatrice S., Mostaghel, Elahe A., Ye, Huihui, Garraway, Isla P., You, Sungyong, Freeman, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614109/
https://www.ncbi.nlm.nih.gov/pubmed/37905039
http://dx.doi.org/10.1101/2023.09.28.560025

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