Identification of a 1,2,4-Oxadiazole with Potent and Specific Activity against Clostridioides difficile, the Causative Bacterium of C. difficile Infection, an Urgent Public Health Threat

The discovery of compound 57, a new, totally synthetic 1,2,4-oxadiazole antibacterial agent, is described. This oxadiazole displays highly selective, bactericidal killing of Clostridioides (Clostridium) difficile, the bacterium that causes C. difficile infection (CDI) in both hospital and community...

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Detalles Bibliográficos
Autor principal: Barbachyn, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614189/
https://www.ncbi.nlm.nih.gov/pubmed/37823241
http://dx.doi.org/10.1021/acs.jmedchem.3c01778
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author Barbachyn, Michael R.
author_facet Barbachyn, Michael R.
author_sort Barbachyn, Michael R.
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description The discovery of compound 57, a new, totally synthetic 1,2,4-oxadiazole antibacterial agent, is described. This oxadiazole displays highly selective, bactericidal killing of Clostridioides (Clostridium) difficile, the bacterium that causes C. difficile infection (CDI) in both hospital and community settings. The narrow spectrum of activity exhibited by 57 should avoid any disruption of commensal anaerobic bacteria in the gut microbiome, minimizing chances for recurrent CDI.
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spelling pubmed-106141892023-10-31 Identification of a 1,2,4-Oxadiazole with Potent and Specific Activity against Clostridioides difficile, the Causative Bacterium of C. difficile Infection, an Urgent Public Health Threat Barbachyn, Michael R. J Med Chem The discovery of compound 57, a new, totally synthetic 1,2,4-oxadiazole antibacterial agent, is described. This oxadiazole displays highly selective, bactericidal killing of Clostridioides (Clostridium) difficile, the bacterium that causes C. difficile infection (CDI) in both hospital and community settings. The narrow spectrum of activity exhibited by 57 should avoid any disruption of commensal anaerobic bacteria in the gut microbiome, minimizing chances for recurrent CDI. American Chemical Society 2023-10-12 /pmc/articles/PMC10614189/ /pubmed/37823241 http://dx.doi.org/10.1021/acs.jmedchem.3c01778 Text en © 2023 The Author. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Barbachyn, Michael R.
Identification of a 1,2,4-Oxadiazole with Potent and Specific Activity against Clostridioides difficile, the Causative Bacterium of C. difficile Infection, an Urgent Public Health Threat
title Identification of a 1,2,4-Oxadiazole with Potent and Specific Activity against Clostridioides difficile, the Causative Bacterium of C. difficile Infection, an Urgent Public Health Threat
title_full Identification of a 1,2,4-Oxadiazole with Potent and Specific Activity against Clostridioides difficile, the Causative Bacterium of C. difficile Infection, an Urgent Public Health Threat
title_fullStr Identification of a 1,2,4-Oxadiazole with Potent and Specific Activity against Clostridioides difficile, the Causative Bacterium of C. difficile Infection, an Urgent Public Health Threat
title_full_unstemmed Identification of a 1,2,4-Oxadiazole with Potent and Specific Activity against Clostridioides difficile, the Causative Bacterium of C. difficile Infection, an Urgent Public Health Threat
title_short Identification of a 1,2,4-Oxadiazole with Potent and Specific Activity against Clostridioides difficile, the Causative Bacterium of C. difficile Infection, an Urgent Public Health Threat
title_sort identification of a 1,2,4-oxadiazole with potent and specific activity against clostridioides difficile, the causative bacterium of c. difficile infection, an urgent public health threat
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614189/
https://www.ncbi.nlm.nih.gov/pubmed/37823241
http://dx.doi.org/10.1021/acs.jmedchem.3c01778
work_keys_str_mv AT barbachynmichaelr identificationofa124oxadiazolewithpotentandspecificactivityagainstclostridioidesdifficilethecausativebacteriumofcdifficileinfectionanurgentpublichealththreat

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