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Biphasic decay of intact SHIV genomes following initiation of antiretroviral therapy complicates analysis of interventions targeting the reservoir

The latent reservoir for HIV-1 in resting CD4(+) T cells persists despite antiretroviral therapy (ART) and precludes cure. Reservoir-targeting interventions are evaluated in ART-treated macaques infected with simian immunodeficiency virus (SIV) or simian-human immunodeficiency virus (SHIV). Efficacy...

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Detalles Bibliográficos
Autores principales:	Kumar, Mithra R., Fray, Emily J., Bender, Alexandra M., Zitzmann, Carolin, Ribeiro, Ruy M., Perelson, Alan S., Barouch, Dan H., Siliciano, Janet D., Siliciano, Robert F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2023
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614214/ https://www.ncbi.nlm.nih.gov/pubmed/37844236 http://dx.doi.org/10.1073/pnas.2313209120

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