Dendrimer-Conjugated Glutamate Carboxypeptidase II Inhibitor Restores Microglial Changes in a Rabbit Model of Cerebral Palsy

We have previously shown that maternal endotoxin exposure leads to a phenotype of cerebral palsy and pro-inflammatory microglia in the brain in neonatal rabbits. “Activated” microglia overexpress the enzyme glutamate carboxypeptidase II (GCPII) that hydrolyzes N-acetylaspartylglutamate to N-acetylas...

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Detalles Bibliográficos
Autores principales: Sah, Nirnath, Zhang, Zhi, Chime, Alicia, Fowler, Amanda, Mendez-Trendler, Antonio, Sharma, Anjali, Kannan, Rangaramanujam M., Slusher, Barbara, Kannan, Sujatha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2023
Materias:
Neurodevelopmental Consequences of Perinatal Brain Injuries: Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614263/
https://www.ncbi.nlm.nih.gov/pubmed/36990069
http://dx.doi.org/10.1159/000530389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614263/
https://www.ncbi.nlm.nih.gov/pubmed/36990069
http://dx.doi.org/10.1159/000530389

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