Bcl-B: an “unknown” protein of the Bcl-2 family

Bcl-B is a poorly understood protein of the Bcl-2 family that is highly expressed in many healthy tissues and tumor types. Bcl-B is considered an antiapoptotic protein, but many reports have revealed its contradictory roles in different cancer types. In this mini-review, we elucidate the functions o...

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Detalles Bibliográficos
Autores principales: Pervushin, N. V., Kopeina, G. S., Zhivotovsky, B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614328/
https://www.ncbi.nlm.nih.gov/pubmed/37899453
http://dx.doi.org/10.1186/s13062-023-00431-4
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author Pervushin, N. V.
Kopeina, G. S.
Zhivotovsky, B.
author_facet Pervushin, N. V.
Kopeina, G. S.
Zhivotovsky, B.
author_sort Pervushin, N. V.
collection PubMed
description Bcl-B is a poorly understood protein of the Bcl-2 family that is highly expressed in many healthy tissues and tumor types. Bcl-B is considered an antiapoptotic protein, but many reports have revealed its contradictory roles in different cancer types. In this mini-review, we elucidate the functions of Bcl-B in normal conditions and various pathologies, its regulation of programmed cell death, its oncogene/oncosuppressor activity in tumorigenesis, its impact on drug-acquired resistance, and possible approaches to inhibit Bcl-B.
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spelling pubmed-106143282023-10-31 Bcl-B: an “unknown” protein of the Bcl-2 family Pervushin, N. V. Kopeina, G. S. Zhivotovsky, B. Biol Direct Review Bcl-B is a poorly understood protein of the Bcl-2 family that is highly expressed in many healthy tissues and tumor types. Bcl-B is considered an antiapoptotic protein, but many reports have revealed its contradictory roles in different cancer types. In this mini-review, we elucidate the functions of Bcl-B in normal conditions and various pathologies, its regulation of programmed cell death, its oncogene/oncosuppressor activity in tumorigenesis, its impact on drug-acquired resistance, and possible approaches to inhibit Bcl-B. BioMed Central 2023-10-30 /pmc/articles/PMC10614328/ /pubmed/37899453 http://dx.doi.org/10.1186/s13062-023-00431-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Pervushin, N. V.
Kopeina, G. S.
Zhivotovsky, B.
Bcl-B: an “unknown” protein of the Bcl-2 family
title Bcl-B: an “unknown” protein of the Bcl-2 family
title_full Bcl-B: an “unknown” protein of the Bcl-2 family
title_fullStr Bcl-B: an “unknown” protein of the Bcl-2 family
title_full_unstemmed Bcl-B: an “unknown” protein of the Bcl-2 family
title_short Bcl-B: an “unknown” protein of the Bcl-2 family
title_sort bcl-b: an “unknown” protein of the bcl-2 family
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614328/
https://www.ncbi.nlm.nih.gov/pubmed/37899453
http://dx.doi.org/10.1186/s13062-023-00431-4
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