Biological function and clinical application prospect of tsRNAs in digestive system biology and pathology

tsRNAs are small non-coding RNAs originating from tRNA that play important roles in a variety of physiological activities such as RNA silencing, ribosome biogenesis, retrotransposition, and epigenetic inheritance, as well as involvement in cellular differentiation, proliferation, and apoptosis. tsRN...

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Autores principales: Du, Juan, Huang, Tianyi, Zheng, Zhen, Fang, Shuai, Deng, Hongxia, Liu, Kaitai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614346/
https://www.ncbi.nlm.nih.gov/pubmed/37904174
http://dx.doi.org/10.1186/s12964-023-01341-8
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author Du, Juan
Huang, Tianyi
Zheng, Zhen
Fang, Shuai
Deng, Hongxia
Liu, Kaitai
author_facet Du, Juan
Huang, Tianyi
Zheng, Zhen
Fang, Shuai
Deng, Hongxia
Liu, Kaitai
author_sort Du, Juan
collection PubMed
description tsRNAs are small non-coding RNAs originating from tRNA that play important roles in a variety of physiological activities such as RNA silencing, ribosome biogenesis, retrotransposition, and epigenetic inheritance, as well as involvement in cellular differentiation, proliferation, and apoptosis. tsRNA-related abnormalities have a significant influence on the onset, development, and progression of numerous human diseases, including malignant tumors through affecting the cell cycle and specific signaling molecules. This review introduced origins together with tsRNAs classification, providing a summary for regulatory mechanism and physiological function while dysfunctional effect of tsRNAs in digestive system diseases, focusing on the clinical prospects of tsRNAs for diagnostic and prognostic biomarkers. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-023-01341-8.
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spelling pubmed-106143462023-10-31 Biological function and clinical application prospect of tsRNAs in digestive system biology and pathology Du, Juan Huang, Tianyi Zheng, Zhen Fang, Shuai Deng, Hongxia Liu, Kaitai Cell Commun Signal Review tsRNAs are small non-coding RNAs originating from tRNA that play important roles in a variety of physiological activities such as RNA silencing, ribosome biogenesis, retrotransposition, and epigenetic inheritance, as well as involvement in cellular differentiation, proliferation, and apoptosis. tsRNA-related abnormalities have a significant influence on the onset, development, and progression of numerous human diseases, including malignant tumors through affecting the cell cycle and specific signaling molecules. This review introduced origins together with tsRNAs classification, providing a summary for regulatory mechanism and physiological function while dysfunctional effect of tsRNAs in digestive system diseases, focusing on the clinical prospects of tsRNAs for diagnostic and prognostic biomarkers. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-023-01341-8. BioMed Central 2023-10-30 /pmc/articles/PMC10614346/ /pubmed/37904174 http://dx.doi.org/10.1186/s12964-023-01341-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Du, Juan
Huang, Tianyi
Zheng, Zhen
Fang, Shuai
Deng, Hongxia
Liu, Kaitai
Biological function and clinical application prospect of tsRNAs in digestive system biology and pathology
title Biological function and clinical application prospect of tsRNAs in digestive system biology and pathology
title_full Biological function and clinical application prospect of tsRNAs in digestive system biology and pathology
title_fullStr Biological function and clinical application prospect of tsRNAs in digestive system biology and pathology
title_full_unstemmed Biological function and clinical application prospect of tsRNAs in digestive system biology and pathology
title_short Biological function and clinical application prospect of tsRNAs in digestive system biology and pathology
title_sort biological function and clinical application prospect of tsrnas in digestive system biology and pathology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614346/
https://www.ncbi.nlm.nih.gov/pubmed/37904174
http://dx.doi.org/10.1186/s12964-023-01341-8
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