LRRK2 is involved in the chemotaxis of neutrophils and differentiated HL-60 cells, and the inhibition of LRRK2 kinase activity increases fMLP-induced chemotactic activity

BACKGROUND: Neutrophils depend heavily on glycolysis for energy production under normal conditions. In contrast, neutrophils require energy supplied by mitochondrial oxidative phosphorylation (OXPHOS) during chemotaxis. However, the mechanism by which the energy supply changes from glycolysis to OXP...

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Detalles Bibliográficos
Autores principales: Mazaki, Yuichi, Handa, Haruka, Fumoto, Yoshizuki, Horinouchi, Takahiro, Onodera, Yasuhito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614378/
https://www.ncbi.nlm.nih.gov/pubmed/37904222
http://dx.doi.org/10.1186/s12964-023-01305-y

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