Dedifferentiated endometrial carcinoma metastasis to axillary lymph node: a case report

BACKGROUND: We present an unusual case of a left axillary lymph node metastasis from a primary dedifferentiated endometrial carcinoma. This pattern of metastasis is likely the result of circulating tumor cells reaching the node through its arterial blood supply. CASE PRESENTATION: In this report, a...

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Autores principales: Morrison, Chase William, Sanjasaz, Kayvon Nick, Nathanson, Saul David, Raina-Hukku, Supriya, Pinkney, David Matthew, Davenport, Alexis Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614416/
https://www.ncbi.nlm.nih.gov/pubmed/37899461
http://dx.doi.org/10.1186/s13256-023-04192-6
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author Morrison, Chase William
Sanjasaz, Kayvon Nick
Nathanson, Saul David
Raina-Hukku, Supriya
Pinkney, David Matthew
Davenport, Alexis Anna
author_facet Morrison, Chase William
Sanjasaz, Kayvon Nick
Nathanson, Saul David
Raina-Hukku, Supriya
Pinkney, David Matthew
Davenport, Alexis Anna
author_sort Morrison, Chase William
collection PubMed
description BACKGROUND: We present an unusual case of a left axillary lymph node metastasis from a primary dedifferentiated endometrial carcinoma. This pattern of metastasis is likely the result of circulating tumor cells reaching the node through its arterial blood supply. CASE PRESENTATION: In this report, a 68-year-old white woman with a dedifferentiated endometrial carcinoma underwent a hysterectomy. She later developed an enlarged axillary lymph node due to metastatic dedifferentiated endometrial carcinoma, treated with chemotherapy and anti-programmed cell death protein 1 immunotherapy resulting in a complete clinical and radiological response. CONCLUSION: A review of the literature reveals the rarity of blood-borne lymph node metastasis, especially with uterine carcinoma. Immunotherapy has shown promising results in the treatment of some subtypes of metastatic uterine carcinoma.
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spelling pubmed-106144162023-10-31 Dedifferentiated endometrial carcinoma metastasis to axillary lymph node: a case report Morrison, Chase William Sanjasaz, Kayvon Nick Nathanson, Saul David Raina-Hukku, Supriya Pinkney, David Matthew Davenport, Alexis Anna J Med Case Rep Case Report BACKGROUND: We present an unusual case of a left axillary lymph node metastasis from a primary dedifferentiated endometrial carcinoma. This pattern of metastasis is likely the result of circulating tumor cells reaching the node through its arterial blood supply. CASE PRESENTATION: In this report, a 68-year-old white woman with a dedifferentiated endometrial carcinoma underwent a hysterectomy. She later developed an enlarged axillary lymph node due to metastatic dedifferentiated endometrial carcinoma, treated with chemotherapy and anti-programmed cell death protein 1 immunotherapy resulting in a complete clinical and radiological response. CONCLUSION: A review of the literature reveals the rarity of blood-borne lymph node metastasis, especially with uterine carcinoma. Immunotherapy has shown promising results in the treatment of some subtypes of metastatic uterine carcinoma. BioMed Central 2023-10-30 /pmc/articles/PMC10614416/ /pubmed/37899461 http://dx.doi.org/10.1186/s13256-023-04192-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Morrison, Chase William
Sanjasaz, Kayvon Nick
Nathanson, Saul David
Raina-Hukku, Supriya
Pinkney, David Matthew
Davenport, Alexis Anna
Dedifferentiated endometrial carcinoma metastasis to axillary lymph node: a case report
title Dedifferentiated endometrial carcinoma metastasis to axillary lymph node: a case report
title_full Dedifferentiated endometrial carcinoma metastasis to axillary lymph node: a case report
title_fullStr Dedifferentiated endometrial carcinoma metastasis to axillary lymph node: a case report
title_full_unstemmed Dedifferentiated endometrial carcinoma metastasis to axillary lymph node: a case report
title_short Dedifferentiated endometrial carcinoma metastasis to axillary lymph node: a case report
title_sort dedifferentiated endometrial carcinoma metastasis to axillary lymph node: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614416/
https://www.ncbi.nlm.nih.gov/pubmed/37899461
http://dx.doi.org/10.1186/s13256-023-04192-6
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