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Distribution of the Retinal Microcirculation Based on the Morphology of Peripapillary Atrophy in High Myopia
INTRODUCTION: The objective of this study was to evaluate the retinal microvasculature of the optic nerve head and macula in high myopia (HM), investigate the association between the vascular parameters and peripapillary atrophy (PPA) deformation, and assess and identify the PPA morphology changes d...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614452/ https://www.ncbi.nlm.nih.gov/pubmed/37459845 http://dx.doi.org/10.1159/000531509 |
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author | Tang, Wenquan Ouyang, Junyi Luo, YuLin |
author_facet | Tang, Wenquan Ouyang, Junyi Luo, YuLin |
author_sort | Tang, Wenquan |
collection | PubMed |
description | INTRODUCTION: The objective of this study was to evaluate the retinal microvasculature of the optic nerve head and macula in high myopia (HM), investigate the association between the vascular parameters and peripapillary atrophy (PPA) deformation, and assess and identify the PPA morphology changes during the development of HM. METHODS: One hundred sixty-seven right eyes from 167 HM patients were enrolled in this cross-sectional study. Using the optical coherence tomography angiography (OCTA) and fundus camera, we evaluated the following parameters: radian and type of PPA, intrapapillary vascular density (IVD), peripapillary vascular density (PVD), macular vascular density (MVD), and foveal avascular zone (FAZ). Based on the PPA radian, subjects were divided into four groups: the non-PPA, temporal PPA, advanced PPA, and annular PPA. At the same time, the above parameters were compared between the groups using analysis of variance (ANOVA) and least significant difference test. RESULTS: Total enrolled patients were divided into the non-PPA group (22 eyes), temporal-PPA group (70 eyes), advanced-PPA group (60 eyes), and annular-PPA group (15 eyes). The results showed that the PVD in the annular-PPA group was smaller than that in the non-PPA group, especially in the superonasal, nasosuperior, nasoinferior, inferotemporal, temporoinferior, and superotemporal directions (F = 4.059, 5.014, 2.830, 4.798, 5.892, 3.439; p < 0.05). Notably, the PVD showcased the highest value in temporal, followed by that in superior and inferior, and the lowest in the nasal. Concerning the fovea deep macular vascular density, FAZ area, and subfoveal choroidal thickness in the annular-PPA group, they were less than those of the rest of the groups (p < 0.05). CONCLUSION: The retinal microvasculature differed significantly in HM according to the PPA morphology. In addition to PVD and SFCT, the PPA can also affect FAZ. Finally, we speculated that PVD demonstrated better predictability of myopic progression than MVD. |
format | Online Article Text |
id | pubmed-10614452 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-106144522023-10-31 Distribution of the Retinal Microcirculation Based on the Morphology of Peripapillary Atrophy in High Myopia Tang, Wenquan Ouyang, Junyi Luo, YuLin Ophthalmic Res Research Article INTRODUCTION: The objective of this study was to evaluate the retinal microvasculature of the optic nerve head and macula in high myopia (HM), investigate the association between the vascular parameters and peripapillary atrophy (PPA) deformation, and assess and identify the PPA morphology changes during the development of HM. METHODS: One hundred sixty-seven right eyes from 167 HM patients were enrolled in this cross-sectional study. Using the optical coherence tomography angiography (OCTA) and fundus camera, we evaluated the following parameters: radian and type of PPA, intrapapillary vascular density (IVD), peripapillary vascular density (PVD), macular vascular density (MVD), and foveal avascular zone (FAZ). Based on the PPA radian, subjects were divided into four groups: the non-PPA, temporal PPA, advanced PPA, and annular PPA. At the same time, the above parameters were compared between the groups using analysis of variance (ANOVA) and least significant difference test. RESULTS: Total enrolled patients were divided into the non-PPA group (22 eyes), temporal-PPA group (70 eyes), advanced-PPA group (60 eyes), and annular-PPA group (15 eyes). The results showed that the PVD in the annular-PPA group was smaller than that in the non-PPA group, especially in the superonasal, nasosuperior, nasoinferior, inferotemporal, temporoinferior, and superotemporal directions (F = 4.059, 5.014, 2.830, 4.798, 5.892, 3.439; p < 0.05). Notably, the PVD showcased the highest value in temporal, followed by that in superior and inferior, and the lowest in the nasal. Concerning the fovea deep macular vascular density, FAZ area, and subfoveal choroidal thickness in the annular-PPA group, they were less than those of the rest of the groups (p < 0.05). CONCLUSION: The retinal microvasculature differed significantly in HM according to the PPA morphology. In addition to PVD and SFCT, the PPA can also affect FAZ. Finally, we speculated that PVD demonstrated better predictability of myopic progression than MVD. S. Karger AG 2023-07-17 /pmc/articles/PMC10614452/ /pubmed/37459845 http://dx.doi.org/10.1159/000531509 Text en © 2023 The Author(s).Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission. |
spellingShingle | Research Article Tang, Wenquan Ouyang, Junyi Luo, YuLin Distribution of the Retinal Microcirculation Based on the Morphology of Peripapillary Atrophy in High Myopia |
title | Distribution of the Retinal Microcirculation Based on the Morphology of Peripapillary Atrophy in High Myopia |
title_full | Distribution of the Retinal Microcirculation Based on the Morphology of Peripapillary Atrophy in High Myopia |
title_fullStr | Distribution of the Retinal Microcirculation Based on the Morphology of Peripapillary Atrophy in High Myopia |
title_full_unstemmed | Distribution of the Retinal Microcirculation Based on the Morphology of Peripapillary Atrophy in High Myopia |
title_short | Distribution of the Retinal Microcirculation Based on the Morphology of Peripapillary Atrophy in High Myopia |
title_sort | distribution of the retinal microcirculation based on the morphology of peripapillary atrophy in high myopia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614452/ https://www.ncbi.nlm.nih.gov/pubmed/37459845 http://dx.doi.org/10.1159/000531509 |
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