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Distribution of the Retinal Microcirculation Based on the Morphology of Peripapillary Atrophy in High Myopia

INTRODUCTION: The objective of this study was to evaluate the retinal microvasculature of the optic nerve head and macula in high myopia (HM), investigate the association between the vascular parameters and peripapillary atrophy (PPA) deformation, and assess and identify the PPA morphology changes d...

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Detalles Bibliográficos
Autores principales: Tang, Wenquan, Ouyang, Junyi, Luo, YuLin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614452/
https://www.ncbi.nlm.nih.gov/pubmed/37459845
http://dx.doi.org/10.1159/000531509
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author Tang, Wenquan
Ouyang, Junyi
Luo, YuLin
author_facet Tang, Wenquan
Ouyang, Junyi
Luo, YuLin
author_sort Tang, Wenquan
collection PubMed
description INTRODUCTION: The objective of this study was to evaluate the retinal microvasculature of the optic nerve head and macula in high myopia (HM), investigate the association between the vascular parameters and peripapillary atrophy (PPA) deformation, and assess and identify the PPA morphology changes during the development of HM. METHODS: One hundred sixty-seven right eyes from 167 HM patients were enrolled in this cross-sectional study. Using the optical coherence tomography angiography (OCTA) and fundus camera, we evaluated the following parameters: radian and type of PPA, intrapapillary vascular density (IVD), peripapillary vascular density (PVD), macular vascular density (MVD), and foveal avascular zone (FAZ). Based on the PPA radian, subjects were divided into four groups: the non-PPA, temporal PPA, advanced PPA, and annular PPA. At the same time, the above parameters were compared between the groups using analysis of variance (ANOVA) and least significant difference test. RESULTS: Total enrolled patients were divided into the non-PPA group (22 eyes), temporal-PPA group (70 eyes), advanced-PPA group (60 eyes), and annular-PPA group (15 eyes). The results showed that the PVD in the annular-PPA group was smaller than that in the non-PPA group, especially in the superonasal, nasosuperior, nasoinferior, inferotemporal, temporoinferior, and superotemporal directions (F = 4.059, 5.014, 2.830, 4.798, 5.892, 3.439; p < 0.05). Notably, the PVD showcased the highest value in temporal, followed by that in superior and inferior, and the lowest in the nasal. Concerning the fovea deep macular vascular density, FAZ area, and subfoveal choroidal thickness in the annular-PPA group, they were less than those of the rest of the groups (p < 0.05). CONCLUSION: The retinal microvasculature differed significantly in HM according to the PPA morphology. In addition to PVD and SFCT, the PPA can also affect FAZ. Finally, we speculated that PVD demonstrated better predictability of myopic progression than MVD.
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spelling pubmed-106144522023-10-31 Distribution of the Retinal Microcirculation Based on the Morphology of Peripapillary Atrophy in High Myopia Tang, Wenquan Ouyang, Junyi Luo, YuLin Ophthalmic Res Research Article INTRODUCTION: The objective of this study was to evaluate the retinal microvasculature of the optic nerve head and macula in high myopia (HM), investigate the association between the vascular parameters and peripapillary atrophy (PPA) deformation, and assess and identify the PPA morphology changes during the development of HM. METHODS: One hundred sixty-seven right eyes from 167 HM patients were enrolled in this cross-sectional study. Using the optical coherence tomography angiography (OCTA) and fundus camera, we evaluated the following parameters: radian and type of PPA, intrapapillary vascular density (IVD), peripapillary vascular density (PVD), macular vascular density (MVD), and foveal avascular zone (FAZ). Based on the PPA radian, subjects were divided into four groups: the non-PPA, temporal PPA, advanced PPA, and annular PPA. At the same time, the above parameters were compared between the groups using analysis of variance (ANOVA) and least significant difference test. RESULTS: Total enrolled patients were divided into the non-PPA group (22 eyes), temporal-PPA group (70 eyes), advanced-PPA group (60 eyes), and annular-PPA group (15 eyes). The results showed that the PVD in the annular-PPA group was smaller than that in the non-PPA group, especially in the superonasal, nasosuperior, nasoinferior, inferotemporal, temporoinferior, and superotemporal directions (F = 4.059, 5.014, 2.830, 4.798, 5.892, 3.439; p < 0.05). Notably, the PVD showcased the highest value in temporal, followed by that in superior and inferior, and the lowest in the nasal. Concerning the fovea deep macular vascular density, FAZ area, and subfoveal choroidal thickness in the annular-PPA group, they were less than those of the rest of the groups (p < 0.05). CONCLUSION: The retinal microvasculature differed significantly in HM according to the PPA morphology. In addition to PVD and SFCT, the PPA can also affect FAZ. Finally, we speculated that PVD demonstrated better predictability of myopic progression than MVD. S. Karger AG 2023-07-17 /pmc/articles/PMC10614452/ /pubmed/37459845 http://dx.doi.org/10.1159/000531509 Text en © 2023 The Author(s).Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Research Article
Tang, Wenquan
Ouyang, Junyi
Luo, YuLin
Distribution of the Retinal Microcirculation Based on the Morphology of Peripapillary Atrophy in High Myopia
title Distribution of the Retinal Microcirculation Based on the Morphology of Peripapillary Atrophy in High Myopia
title_full Distribution of the Retinal Microcirculation Based on the Morphology of Peripapillary Atrophy in High Myopia
title_fullStr Distribution of the Retinal Microcirculation Based on the Morphology of Peripapillary Atrophy in High Myopia
title_full_unstemmed Distribution of the Retinal Microcirculation Based on the Morphology of Peripapillary Atrophy in High Myopia
title_short Distribution of the Retinal Microcirculation Based on the Morphology of Peripapillary Atrophy in High Myopia
title_sort distribution of the retinal microcirculation based on the morphology of peripapillary atrophy in high myopia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614452/
https://www.ncbi.nlm.nih.gov/pubmed/37459845
http://dx.doi.org/10.1159/000531509
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