Emodin Inhibits the Indoxyl Sulfate-Induced trans-Differentiation of Vascular Smooth Muscle Cells through Upregulating Thrombospondin-1

BACKGROUND: Indoxyl sulfate (IS) is a protein-bound uremic toxin with vascular toxicity. The primary cause of death in uremic patients on maintenance hemodialysis is vascular disease, and it had been reported that vascular smooth muscle cells (VSMCs) trans-differentiation (VT) plays a vital role in...

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Detalles Bibliográficos
Autores principales: Zhang, Weidong, Chen, Jing, Tan, Xiao, Zhang, Pan, Xu, Xialian, Ding, Xiaoqiang, Zhao, Shuan, Jin, Shi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614470/
https://www.ncbi.nlm.nih.gov/pubmed/37669629
http://dx.doi.org/10.1159/000532028

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