Membrane remodeling properties of the Parkinson’s disease protein LRRK2

Mutations in Leucine-rich repeat kinase 2 (LRRK2) are responsible for late-onset autosomal dominant Parkinson’s disease. LRRK2 has been implicated in a wide range of physiological processes including membrane repair in the endolysosomal system. Here, using cell-free systems, we report that purified...

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Detalles Bibliográficos
Autores principales: Wang, Xinbo, Espadas, Javier, Wu, Yumei, Cai, Shujun, Ge, Jinghua, Shao, Lin, Roux, Aurélien, De Camilli, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614619/
https://www.ncbi.nlm.nih.gov/pubmed/37844218
http://dx.doi.org/10.1073/pnas.2309698120

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