Cargando…

Manganese-Based Nanotheranostics for Magnetic Resonance Imaging-Mediated Precise Cancer Management

Manganese (Mn)-based magnetic resonance imaging (MRI) has become a competitive imaging modality for cancer diagnosis due to its advantages of non-invasiveness, high resolution and excellent biocompatibility. In recent years, a variety of Mn contrast agents based on different material systems have be...

Descripción completa

Detalles Bibliográficos
Autores principales: Du, Ruochen, Zhao, Ziwei, Cui, Jing, Li, Yanan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614655/
https://www.ncbi.nlm.nih.gov/pubmed/37908669
http://dx.doi.org/10.2147/IJN.S426311
_version_ 1785129067039686656
author Du, Ruochen
Zhao, Ziwei
Cui, Jing
Li, Yanan
author_facet Du, Ruochen
Zhao, Ziwei
Cui, Jing
Li, Yanan
author_sort Du, Ruochen
collection PubMed
description Manganese (Mn)-based magnetic resonance imaging (MRI) has become a competitive imaging modality for cancer diagnosis due to its advantages of non-invasiveness, high resolution and excellent biocompatibility. In recent years, a variety of Mn contrast agents based on different material systems have been synthesized, and a series of multi-purpose Mn nanocomposites have also emerged, showing satisfactory relaxation efficiency and MRI performance thus possess the transformation and application value in MRI-synergized cancer diagnosis and treatment. This tutorial review starts from the classification and properties of Mn-based nanomaterials, and then summarizes various preparation and functionalization strategies of nanosized Mn contrast agents, especially focuses on the latest progress of Mn contrast agents in MRI-synergized precise cancer theranostics. In addition, present review also discusses the current clinical transformation obstacles such as unclear molecular mechanisms, potential nanotoxicity, and scale production constraints. This paper provides evidence-based recommendations about the future prospects of multifunctional nanoplatforms, as well as technical guidance and panoramic expectations for the design of clinically meaningful cancer management programs.
format Online
Article
Text
id pubmed-10614655
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-106146552023-10-31 Manganese-Based Nanotheranostics for Magnetic Resonance Imaging-Mediated Precise Cancer Management Du, Ruochen Zhao, Ziwei Cui, Jing Li, Yanan Int J Nanomedicine Review Manganese (Mn)-based magnetic resonance imaging (MRI) has become a competitive imaging modality for cancer diagnosis due to its advantages of non-invasiveness, high resolution and excellent biocompatibility. In recent years, a variety of Mn contrast agents based on different material systems have been synthesized, and a series of multi-purpose Mn nanocomposites have also emerged, showing satisfactory relaxation efficiency and MRI performance thus possess the transformation and application value in MRI-synergized cancer diagnosis and treatment. This tutorial review starts from the classification and properties of Mn-based nanomaterials, and then summarizes various preparation and functionalization strategies of nanosized Mn contrast agents, especially focuses on the latest progress of Mn contrast agents in MRI-synergized precise cancer theranostics. In addition, present review also discusses the current clinical transformation obstacles such as unclear molecular mechanisms, potential nanotoxicity, and scale production constraints. This paper provides evidence-based recommendations about the future prospects of multifunctional nanoplatforms, as well as technical guidance and panoramic expectations for the design of clinically meaningful cancer management programs. Dove 2023-10-26 /pmc/articles/PMC10614655/ /pubmed/37908669 http://dx.doi.org/10.2147/IJN.S426311 Text en © 2023 Du et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Du, Ruochen
Zhao, Ziwei
Cui, Jing
Li, Yanan
Manganese-Based Nanotheranostics for Magnetic Resonance Imaging-Mediated Precise Cancer Management
title Manganese-Based Nanotheranostics for Magnetic Resonance Imaging-Mediated Precise Cancer Management
title_full Manganese-Based Nanotheranostics for Magnetic Resonance Imaging-Mediated Precise Cancer Management
title_fullStr Manganese-Based Nanotheranostics for Magnetic Resonance Imaging-Mediated Precise Cancer Management
title_full_unstemmed Manganese-Based Nanotheranostics for Magnetic Resonance Imaging-Mediated Precise Cancer Management
title_short Manganese-Based Nanotheranostics for Magnetic Resonance Imaging-Mediated Precise Cancer Management
title_sort manganese-based nanotheranostics for magnetic resonance imaging-mediated precise cancer management
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614655/
https://www.ncbi.nlm.nih.gov/pubmed/37908669
http://dx.doi.org/10.2147/IJN.S426311
work_keys_str_mv AT duruochen manganesebasednanotheranosticsformagneticresonanceimagingmediatedprecisecancermanagement
AT zhaoziwei manganesebasednanotheranosticsformagneticresonanceimagingmediatedprecisecancermanagement
AT cuijing manganesebasednanotheranosticsformagneticresonanceimagingmediatedprecisecancermanagement
AT liyanan manganesebasednanotheranosticsformagneticresonanceimagingmediatedprecisecancermanagement