Pervasive biases in proxy GWAS based on parental history of Alzheimer’s disease

Almost every recent Alzheimer’s disease (AD) genome-wide association study (GWAS) has performed meta-analysis to combine studies with clinical diagnosis of AD with studies that use proxy phenotypes based on parental disease history. Here, we report major limitations in current GWAS-by-proxy (GWAX) p...

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Detalles Bibliográficos
Autores principales: Wu, Yuchang, Sun, Zhongxuan, Zheng, Qinwen, Miao, Jiacheng, Dorn, Stephen, Mukherjee, Shubhabrata, Fletcher, Jason M., Lu, Qiongshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614766/
https://www.ncbi.nlm.nih.gov/pubmed/37904974
http://dx.doi.org/10.1101/2023.10.13.562272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614766/
https://www.ncbi.nlm.nih.gov/pubmed/37904974
http://dx.doi.org/10.1101/2023.10.13.562272

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