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Pervasive biases in proxy GWAS based on parental history of Alzheimer’s disease
Almost every recent Alzheimer’s disease (AD) genome-wide association study (GWAS) has performed meta-analysis to combine studies with clinical diagnosis of AD with studies that use proxy phenotypes based on parental disease history. Here, we report major limitations in current GWAS-by-proxy (GWAX) p...
Autores principales: | Wu, Yuchang, Sun, Zhongxuan, Zheng, Qinwen, Miao, Jiacheng, Dorn, Stephen, Mukherjee, Shubhabrata, Fletcher, Jason M., Lu, Qiongshi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614766/ https://www.ncbi.nlm.nih.gov/pubmed/37904974 http://dx.doi.org/10.1101/2023.10.13.562272 |
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