Increased epithelial mTORC1 activity in chronic rhinosinusitis with nasal polyps

BACKGROUND: The airway epithelium plays a central role in the pathogenesis of chronic respiratory diseases such as asthma and chronic rhinosinusitis with nasal polyps (CRSwNP), but the mechanisms by which airway epithelial cells (EpCs) maintain inflammation are poorly understood. OBJECTIVE: We hypot...

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Detalles Bibliográficos
Autores principales: Huang, George X., Hallen, Nils R., Lee, Minkyu, Zheng, Kelly, Wang, Xin, Mandanas, Michael V., Djeddi, Sarah, Fernandez, Daniela, Hacker, Jonathan, Ryan, Tessa, Bergmark, Regan W., Bhattacharyya, Neil, Lee, Stella, Maxfield, Alice Z., Roditi, Rachel E., Buchheit, Kathleen M., Laidlaw, Tanya M., Gern, James E., Hallstrand, Teal S., Ray, Anuradha, Wenzel, Sally E., Boyce, Joshua A., Gutierrez-Arcelus, Maria, Barrett, Nora A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614789/
https://www.ncbi.nlm.nih.gov/pubmed/37904989
http://dx.doi.org/10.1101/2023.10.13.562288

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