Trans-Lesion Synthesis and Mismatch Repair Pathway Crosstalk Defines Chemoresistance and Hypermutation Mechanisms in Glioblastoma

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Almost all Glioblastoma (GBM) are either intrinsically resistant to the chemotherapeutical drug temozolomide (TMZ) or acquire therapy-induced mutations that cause chemoresistance and recurrence. The genome maintenance mechanisms responsible for GBM chemoresistance and hypermutation are unknown. We s...

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Detalles Bibliográficos
Autores principales: Cheng, Xing, An, Jing, Lou, Jitong, Gu, Qisheng, Ding, Weimin, Droby, Gaith, Wang, Yilin, Wang, Chenghao, Gao, Yanzhe, Shelton, Abigail, Satterlee, Andrew Benson, Mann, Breanna Elizabeth, Hsiao, Yun-Chung, Liu, Chih-Wei, Liu, Kun, Hingtgen, Shawn, Wang, Jiguang, Liu, Zhaoliang, Miller, Ryan, Wu, Di, Vaziri, Cyrus, Yang, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614844/
https://www.ncbi.nlm.nih.gov/pubmed/37905107
http://dx.doi.org/10.1101/2023.10.16.562506

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