Comparative analyses of disease-linked missense mutations in the RNA exosome modeled in budding yeast reveal distinct functional consequences in translation

The RNA exosome is an evolutionarily conserved exoribonuclease complex that consists of a 3-subunit cap, a 6-subunit barrel-shaped core, and a catalytic base subunit. Missense mutations in genes encoding structural subunits of the RNA exosome cause a growing family of diseases with diverse pathologi...

Descripción completa

Detalles Bibliográficos
Autores principales: Sterrett, Maria C., Cureton, Lauryn A., Cohen, Lauren N., van Hoof, Ambro, Khoshnevis, Sohail, Fasken, Milo B., Corbett, Anita H., Ghalei, Homa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614903/
https://www.ncbi.nlm.nih.gov/pubmed/37904946
http://dx.doi.org/10.1101/2023.10.18.562946

Ejemplares similares

Ejemplares similares