Mechanism and cellular function of direct membrane binding by the ESCRT and ERES-associated Ca(2+)-sensor ALG-2

Apoptosis Linked Gene-2 (ALG-2) is a multifunctional intracellular Ca(2+) sensor and the archetypal member of the penta-EF hand protein family. ALG-2 functions in the repair of damage to both the plasma and lysosome membranes and in COPII-dependent budding at endoplasmic reticulum exit sites (ERES)....

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Detalles Bibliográficos
Autores principales: Shukla, Sankalp, Chen, Wei, Rao, Shanlin, Yang, Serim, Ou, Chenxi, Larsen, Kevin P., Hummer, Gerhard, Hanson, Phyllis I., Hurley, James H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614929/
https://www.ncbi.nlm.nih.gov/pubmed/37904979
http://dx.doi.org/10.1101/2023.10.17.562764

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