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ERK1/2 Inhibition Alleviates Noise-Induced Hearing Loss While Tempering Down the Immune Response
Noise-induced hearing loss (NIHL) is a major cause of hearing impairment, yet no FDA-approved drugs exist to prevent it. Targeting the mitogen activated protein kinase (MAPK) cellular pathway has emerged as a promising approach to attenuate NIHL. Tizaterkib is an orally bioavailable, highly specific...
Autores principales: | Lutze, Richard D., Ingersoll, Matthew A., Thotam, Alena, Joseph, Anjali, Fernandes, Joshua, Teitz, Tal |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614960/ https://www.ncbi.nlm.nih.gov/pubmed/37905140 http://dx.doi.org/10.1101/2023.10.18.563007 |
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