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ERK1/2 Inhibition Alleviates Noise-Induced Hearing Loss While Tempering Down the Immune Response

Noise-induced hearing loss (NIHL) is a major cause of hearing impairment, yet no FDA-approved drugs exist to prevent it. Targeting the mitogen activated protein kinase (MAPK) cellular pathway has emerged as a promising approach to attenuate NIHL. Tizaterkib is an orally bioavailable, highly specific...

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Detalles Bibliográficos
Autores principales:	Lutze, Richard D., Ingersoll, Matthew A., Thotam, Alena, Joseph, Anjali, Fernandes, Joshua, Teitz, Tal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614960/ https://www.ncbi.nlm.nih.gov/pubmed/37905140 http://dx.doi.org/10.1101/2023.10.18.563007

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