5-hydroxymethylcytosine sequencing in plasma cell-free DNA identifies unique epigenomic features in prostate cancer patients resistant to androgen deprivation therapy

BACKGROUND: Currently there are no biomarkers to identify resistance to androgen-deprivation therapy (ADT) in men with hormone-naive prostate cancer. 5-hydroxymethylcytosines (5hmC) in the gene body are associated with gene activation and are critical for epigenomic regulation of cancer progression....

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Detalles Bibliográficos
Autores principales: Li, Qianxia, Huang, Chiang-Ching, Huang, Shane, Tian, Yijun, Huang, Jinyong, Bitaraf, Amirreza, Dong, Xiaowei, Nevalanen, Marja T., Zhang, Jingsong, Manley, Brandon J., Park, Jong Y., Kohli, Manish, Gore, Elizabeth M., Kilari, Deepak, Wang, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615016/
https://www.ncbi.nlm.nih.gov/pubmed/37904926
http://dx.doi.org/10.1101/2023.10.13.23296758

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