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Gastrointestinal cell injury and perceived symptoms after running the Boston Marathon

Gastrointestinal (GI) disturbances are a prevalent cause of marathon related complaints, and in extreme cases can promote life-threatening conditions such as exertional heat stroke. Our aim was to study intestinal cell injury [via intestinal fatty acid binding protein (I-FABP)] and perceived GI dist...

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Autores principales: Kelly, Melani R., Emerson, Dawn M., McDermott, Brendon P., Atkins, Whitley C., Butts, Cory L., Laursen, R. Mark, Troyanos, Christopher, Duckett, Andrew, Siedlik, Jacob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615131/
https://www.ncbi.nlm.nih.gov/pubmed/37908334
http://dx.doi.org/10.3389/fphys.2023.1268306
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author Kelly, Melani R.
Emerson, Dawn M.
McDermott, Brendon P.
Atkins, Whitley C.
Butts, Cory L.
Laursen, R. Mark
Troyanos, Christopher
Duckett, Andrew
Siedlik, Jacob
author_facet Kelly, Melani R.
Emerson, Dawn M.
McDermott, Brendon P.
Atkins, Whitley C.
Butts, Cory L.
Laursen, R. Mark
Troyanos, Christopher
Duckett, Andrew
Siedlik, Jacob
author_sort Kelly, Melani R.
collection PubMed
description Gastrointestinal (GI) disturbances are a prevalent cause of marathon related complaints, and in extreme cases can promote life-threatening conditions such as exertional heat stroke. Our aim was to study intestinal cell injury [via intestinal fatty acid binding protein (I-FABP)] and perceived GI distress symptoms among marathon runners. We also examined potential risk factors (e.g., inadequate sleep) that could exacerbate GI disturbances in healthy, trained endurance runners. This was a parallel mixed-methods study design. 2019 Boston Marathon participants were recruited via email and subjects completed surveys before the race describing demographics and training history. Participants completed a GI questionnaire to assess presence and severity of symptoms, a survey regarding risk factors (e.g., recent illness, medications) that could promote GI disturbances, and provided a urine sample at three time points (immediately pre-race, post-race, and 24-h post-race). Due to weather, blood samples were only collected immediately and 24-h post-race. A total of 40 runners (males: n = 19, age = 44.9 ± 10.8 years; females: n = 21, age = 44.8 ± 10.6 years) completed this study. I-FABP significantly decreased from post-race (3367.5 ± 2633.5 pg/mL) to 24-h post-race (1657.3 ± 950.7 pg/mL, t (39) = −4.228, p < .001, d = −.669). There was a significant difference in overall GI symptom scores across the three time points (F (2, 39) = 41.37, p < .001). The highest average score occurred post-race (.84 ± .68), compared to pre-race (.09 ± .12) and 24-h post-race (.44 ± .28). Post-race I-FABP (r = .31, p = .048) and post-race urine specific gravity (r = .33, p = .041) were significantly correlated with post-race GI symptom scores. Our study provides further support to the individualized nature of GI disturbances, with participants experiencing a wide range of risk factors that can influence the extent of GI damage and perceived symptoms during and after exercise.
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spelling pubmed-106151312023-10-31 Gastrointestinal cell injury and perceived symptoms after running the Boston Marathon Kelly, Melani R. Emerson, Dawn M. McDermott, Brendon P. Atkins, Whitley C. Butts, Cory L. Laursen, R. Mark Troyanos, Christopher Duckett, Andrew Siedlik, Jacob Front Physiol Physiology Gastrointestinal (GI) disturbances are a prevalent cause of marathon related complaints, and in extreme cases can promote life-threatening conditions such as exertional heat stroke. Our aim was to study intestinal cell injury [via intestinal fatty acid binding protein (I-FABP)] and perceived GI distress symptoms among marathon runners. We also examined potential risk factors (e.g., inadequate sleep) that could exacerbate GI disturbances in healthy, trained endurance runners. This was a parallel mixed-methods study design. 2019 Boston Marathon participants were recruited via email and subjects completed surveys before the race describing demographics and training history. Participants completed a GI questionnaire to assess presence and severity of symptoms, a survey regarding risk factors (e.g., recent illness, medications) that could promote GI disturbances, and provided a urine sample at three time points (immediately pre-race, post-race, and 24-h post-race). Due to weather, blood samples were only collected immediately and 24-h post-race. A total of 40 runners (males: n = 19, age = 44.9 ± 10.8 years; females: n = 21, age = 44.8 ± 10.6 years) completed this study. I-FABP significantly decreased from post-race (3367.5 ± 2633.5 pg/mL) to 24-h post-race (1657.3 ± 950.7 pg/mL, t (39) = −4.228, p < .001, d = −.669). There was a significant difference in overall GI symptom scores across the three time points (F (2, 39) = 41.37, p < .001). The highest average score occurred post-race (.84 ± .68), compared to pre-race (.09 ± .12) and 24-h post-race (.44 ± .28). Post-race I-FABP (r = .31, p = .048) and post-race urine specific gravity (r = .33, p = .041) were significantly correlated with post-race GI symptom scores. Our study provides further support to the individualized nature of GI disturbances, with participants experiencing a wide range of risk factors that can influence the extent of GI damage and perceived symptoms during and after exercise. Frontiers Media S.A. 2023-10-16 /pmc/articles/PMC10615131/ /pubmed/37908334 http://dx.doi.org/10.3389/fphys.2023.1268306 Text en Copyright © 2023 Kelly, Emerson, McDermott, Atkins, Butts, Laursen, Troyanos, Duckett and Siedlik. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Kelly, Melani R.
Emerson, Dawn M.
McDermott, Brendon P.
Atkins, Whitley C.
Butts, Cory L.
Laursen, R. Mark
Troyanos, Christopher
Duckett, Andrew
Siedlik, Jacob
Gastrointestinal cell injury and perceived symptoms after running the Boston Marathon
title Gastrointestinal cell injury and perceived symptoms after running the Boston Marathon
title_full Gastrointestinal cell injury and perceived symptoms after running the Boston Marathon
title_fullStr Gastrointestinal cell injury and perceived symptoms after running the Boston Marathon
title_full_unstemmed Gastrointestinal cell injury and perceived symptoms after running the Boston Marathon
title_short Gastrointestinal cell injury and perceived symptoms after running the Boston Marathon
title_sort gastrointestinal cell injury and perceived symptoms after running the boston marathon
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615131/
https://www.ncbi.nlm.nih.gov/pubmed/37908334
http://dx.doi.org/10.3389/fphys.2023.1268306
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