CRISPR/Cas9-induced DNA breaks trigger crossover, chromosomal loss, and chromothripsis-like rearrangements

DNA double-stranded breaks (DSBs) generated by the Cas9 nuclease are commonly repaired via nonhomologous end-joining (NHEJ) or homologous recombination (HR). However, little is known about unrepaired DSBs and the type of damage they trigger in plants. We designed an assay that detects loss of hetero...

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Detalles Bibliográficos
Autores principales: Samach, Aviva, Mafessoni, Fabrizio, Gross, Or, Melamed-Bessudo, Cathy, Filler-Hayut, Shdema, Dahan-Meir, Tal, Amsellem, Ziva, Pawlowski, Wojciech P, Levy, Avraham A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615209/
https://www.ncbi.nlm.nih.gov/pubmed/37497643
http://dx.doi.org/10.1093/plcell/koad209

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