Ofatumumab Desensitization Protocol: A Case of Refractory Immune Thrombocytopenic Purpura

Chronic immune thrombocytopenic purpura (ITP) is an acquired hematologic condition that involves immune-mediated platelet destruction with resultant bleeding of variable severity. Refractory ITP occurs when patients fail to tolerate and/or respond to multiple treatment modalities. In this case, we e...

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Detalles Bibliográficos
Autores principales: Cochran, Audra L, Schuldt, Meredith M, Quinn, James M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615384/
https://www.ncbi.nlm.nih.gov/pubmed/37908928
http://dx.doi.org/10.7759/cureus.46278
Descripción
Sumario:Chronic immune thrombocytopenic purpura (ITP) is an acquired hematologic condition that involves immune-mediated platelet destruction with resultant bleeding of variable severity. Refractory ITP occurs when patients fail to tolerate and/or respond to multiple treatment modalities. In this case, we examine the clinical course of a 39-year-old female with refractory ITP and discuss how we navigated a multitude of challenges by adapting an established desensitization protocol to meet our patient’s needs. To our knowledge, we describe the first successful desensitization to ofatumumab for use in ITP in the current literature.

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