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Association of LncRNA PCBP1-AS1 with cancer occurrence and development: A review

Long-stranded noncoding RNAs (LncRNAs) are noncoding RNAs >200 nucleotides in length. Polycytidine binding protein 1 antisense LncRNA is abbreviated as LncRNA polycytosine binding protein 1 antisense1 (PCBP1-AS1). Since studies in recent years have revealed the importance of PCBP1-AS1 in human ge...

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Autores principales: Wu, Yanping, Mou, Jie, Liu, Yuling, Zheng, Wenfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615425/
https://www.ncbi.nlm.nih.gov/pubmed/37904442
http://dx.doi.org/10.1097/MD.0000000000035631
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author Wu, Yanping
Mou, Jie
Liu, Yuling
Zheng, Wenfei
author_facet Wu, Yanping
Mou, Jie
Liu, Yuling
Zheng, Wenfei
author_sort Wu, Yanping
collection PubMed
description Long-stranded noncoding RNAs (LncRNAs) are noncoding RNAs >200 nucleotides in length. Polycytidine binding protein 1 antisense LncRNA is abbreviated as LncRNA polycytosine binding protein 1 antisense1 (PCBP1-AS1). Since studies in recent years have revealed the importance of PCBP1-AS1 in human genetic analysis, it is an important member of the LncRNA family. Genetically engineered group analysis of PCBP1-AS1 regulates the progression of cancer in biology. Therefore, it may be an important RNA in the regulation of human cancer. This article summarizes the molecular mechanism and clinical role of PCBP1-AS1 in various tumor types. Taking “PCBP1-AS1” and “cancer” as keywords, this paper analyzed the relationship between PCBP1-AS1 and various tumors by searching PubMed and Geen Medical, and summarized the related regulatory mechanism of PCBP1-AS1. PCBP1-AS1 is a valuable tumor-associated LncRNA that plays different biological roles in different cancers. Overall, it can both promote and inhibit the development of cancer. For example, abnormally high expression in castration-resitant prostate cancer, hepatocellular carcinoma, cervical cancer, glioma, and colorectal cancer promotes the proliferation and progression of these cancers; in contrast, PCBP1-AS1 inhibits cancer proliferation, metastasis, invasion, and recurrence when highly expressed in vulvar squamous cell carcinoma, Hodgkin lymphoma, and lung adenocarcinoma. PCBP1-AS1 regulates the development of multiple tumors, and the specific mechanism needs to be further investigated, which may become a new tumor marker and potential therapeutic target.
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spelling pubmed-106154252023-10-31 Association of LncRNA PCBP1-AS1 with cancer occurrence and development: A review Wu, Yanping Mou, Jie Liu, Yuling Zheng, Wenfei Medicine (Baltimore) 5700 Long-stranded noncoding RNAs (LncRNAs) are noncoding RNAs >200 nucleotides in length. Polycytidine binding protein 1 antisense LncRNA is abbreviated as LncRNA polycytosine binding protein 1 antisense1 (PCBP1-AS1). Since studies in recent years have revealed the importance of PCBP1-AS1 in human genetic analysis, it is an important member of the LncRNA family. Genetically engineered group analysis of PCBP1-AS1 regulates the progression of cancer in biology. Therefore, it may be an important RNA in the regulation of human cancer. This article summarizes the molecular mechanism and clinical role of PCBP1-AS1 in various tumor types. Taking “PCBP1-AS1” and “cancer” as keywords, this paper analyzed the relationship between PCBP1-AS1 and various tumors by searching PubMed and Geen Medical, and summarized the related regulatory mechanism of PCBP1-AS1. PCBP1-AS1 is a valuable tumor-associated LncRNA that plays different biological roles in different cancers. Overall, it can both promote and inhibit the development of cancer. For example, abnormally high expression in castration-resitant prostate cancer, hepatocellular carcinoma, cervical cancer, glioma, and colorectal cancer promotes the proliferation and progression of these cancers; in contrast, PCBP1-AS1 inhibits cancer proliferation, metastasis, invasion, and recurrence when highly expressed in vulvar squamous cell carcinoma, Hodgkin lymphoma, and lung adenocarcinoma. PCBP1-AS1 regulates the development of multiple tumors, and the specific mechanism needs to be further investigated, which may become a new tumor marker and potential therapeutic target. Lippincott Williams & Wilkins 2023-10-27 /pmc/articles/PMC10615425/ /pubmed/37904442 http://dx.doi.org/10.1097/MD.0000000000035631 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 5700
Wu, Yanping
Mou, Jie
Liu, Yuling
Zheng, Wenfei
Association of LncRNA PCBP1-AS1 with cancer occurrence and development: A review
title Association of LncRNA PCBP1-AS1 with cancer occurrence and development: A review
title_full Association of LncRNA PCBP1-AS1 with cancer occurrence and development: A review
title_fullStr Association of LncRNA PCBP1-AS1 with cancer occurrence and development: A review
title_full_unstemmed Association of LncRNA PCBP1-AS1 with cancer occurrence and development: A review
title_short Association of LncRNA PCBP1-AS1 with cancer occurrence and development: A review
title_sort association of lncrna pcbp1-as1 with cancer occurrence and development: a review
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615425/
https://www.ncbi.nlm.nih.gov/pubmed/37904442
http://dx.doi.org/10.1097/MD.0000000000035631
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