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Association of lncRNA SOX2OT rs9839776 polymorphism with gastric cancer risk in Korean: Case-control study

Aberrant regulation of the long non-coding RNA SRY-box transcription factor 2 overlapping transcript (SOX2OT) has been reported in various diseases including gastric cancer (GC). However, an association between the well-studied rs9839776 single nucleotide polymorphism in SOX2OT and GC susceptibility...

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Autores principales: Hong, Jang Hee, Jin, Eun-Heui, Sung, Jae Kyu, Chang, In Ae, Kang, Hyojin, Lee, Sang-Il
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615517/
https://www.ncbi.nlm.nih.gov/pubmed/37904476
http://dx.doi.org/10.1097/MD.0000000000035103
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author Hong, Jang Hee
Jin, Eun-Heui
Sung, Jae Kyu
Chang, In Ae
Kang, Hyojin
Lee, Sang-Il
author_facet Hong, Jang Hee
Jin, Eun-Heui
Sung, Jae Kyu
Chang, In Ae
Kang, Hyojin
Lee, Sang-Il
author_sort Hong, Jang Hee
collection PubMed
description Aberrant regulation of the long non-coding RNA SRY-box transcription factor 2 overlapping transcript (SOX2OT) has been reported in various diseases including gastric cancer (GC). However, an association between the well-studied rs9839776 single nucleotide polymorphism in SOX2OT and GC susceptibility has not been reported. This study aimed to evaluate the association between the rs9839776 single nucleotide polymorphism in SOX2OT and GC risk. Genotyping of rs9839776 was conducted using TaqMan genotyping assay for 460 patients with GC and 386 controls. We found that the dominant model (CT+TT) and rs9839776 T allele were significantly associated with decreased GC risk (P = .046, adjusted odds ratio [AOR] = 0.72, 95% confidence interval [CI] = 0.52–1.00 and P = .044, AOR = 0.74, 95% CI = 0.56–0.99, respectively). In addition, stratified analysis revealed that the dominant model (CT+TT) and rs9839776 T allele were significantly associated with decreased risk of lymph node metastasis-negative (P = .039, AOR = 0.67, 95% CI = 0.46–0.98 and P = .049, AOR = 0.71, 95% CI = 0.51–1.00, respectively) and tumor stage I (A+B)/II (A+B+C) (P = .028, AOR = 0.66, 95% CI = 0.50–0.96 and P = .041, AOR = 0.71, 95% CI = 0.52–0.99, respectively) GC. Our findings suggest that the rs9839776 T allele may be a protective factor against GC susceptibility. Further research is needed to clarify whether rs9839776 affects SOX2OT expression.
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spelling pubmed-106155172023-10-31 Association of lncRNA SOX2OT rs9839776 polymorphism with gastric cancer risk in Korean: Case-control study Hong, Jang Hee Jin, Eun-Heui Sung, Jae Kyu Chang, In Ae Kang, Hyojin Lee, Sang-Il Medicine (Baltimore) 3500 Aberrant regulation of the long non-coding RNA SRY-box transcription factor 2 overlapping transcript (SOX2OT) has been reported in various diseases including gastric cancer (GC). However, an association between the well-studied rs9839776 single nucleotide polymorphism in SOX2OT and GC susceptibility has not been reported. This study aimed to evaluate the association between the rs9839776 single nucleotide polymorphism in SOX2OT and GC risk. Genotyping of rs9839776 was conducted using TaqMan genotyping assay for 460 patients with GC and 386 controls. We found that the dominant model (CT+TT) and rs9839776 T allele were significantly associated with decreased GC risk (P = .046, adjusted odds ratio [AOR] = 0.72, 95% confidence interval [CI] = 0.52–1.00 and P = .044, AOR = 0.74, 95% CI = 0.56–0.99, respectively). In addition, stratified analysis revealed that the dominant model (CT+TT) and rs9839776 T allele were significantly associated with decreased risk of lymph node metastasis-negative (P = .039, AOR = 0.67, 95% CI = 0.46–0.98 and P = .049, AOR = 0.71, 95% CI = 0.51–1.00, respectively) and tumor stage I (A+B)/II (A+B+C) (P = .028, AOR = 0.66, 95% CI = 0.50–0.96 and P = .041, AOR = 0.71, 95% CI = 0.52–0.99, respectively) GC. Our findings suggest that the rs9839776 T allele may be a protective factor against GC susceptibility. Further research is needed to clarify whether rs9839776 affects SOX2OT expression. Lippincott Williams & Wilkins 2023-10-27 /pmc/articles/PMC10615517/ /pubmed/37904476 http://dx.doi.org/10.1097/MD.0000000000035103 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle 3500
Hong, Jang Hee
Jin, Eun-Heui
Sung, Jae Kyu
Chang, In Ae
Kang, Hyojin
Lee, Sang-Il
Association of lncRNA SOX2OT rs9839776 polymorphism with gastric cancer risk in Korean: Case-control study
title Association of lncRNA SOX2OT rs9839776 polymorphism with gastric cancer risk in Korean: Case-control study
title_full Association of lncRNA SOX2OT rs9839776 polymorphism with gastric cancer risk in Korean: Case-control study
title_fullStr Association of lncRNA SOX2OT rs9839776 polymorphism with gastric cancer risk in Korean: Case-control study
title_full_unstemmed Association of lncRNA SOX2OT rs9839776 polymorphism with gastric cancer risk in Korean: Case-control study
title_short Association of lncRNA SOX2OT rs9839776 polymorphism with gastric cancer risk in Korean: Case-control study
title_sort association of lncrna sox2ot rs9839776 polymorphism with gastric cancer risk in korean: case-control study
topic 3500
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615517/
https://www.ncbi.nlm.nih.gov/pubmed/37904476
http://dx.doi.org/10.1097/MD.0000000000035103
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