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Expression of MMP-14 and its role in bone destruction in middle ear cholesteatoma: A prospective observational study

Cholesteatoma is a noncancerous cystic lesion caused by an abnormal growth of keratinizing squamous epithelium which is invasive and capable of destroying structures. A prospective study on the expression of membrane type1-matrix metalloproteinases (MMP-14) and its related influencing factors in mid...

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Autores principales: Lei, Yu, An, Junjun, Ren, Qingchun, Wang, Minjun, Gao, Mingzhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615539/
https://www.ncbi.nlm.nih.gov/pubmed/37904429
http://dx.doi.org/10.1097/MD.0000000000035538
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author Lei, Yu
An, Junjun
Ren, Qingchun
Wang, Minjun
Gao, Mingzhu
author_facet Lei, Yu
An, Junjun
Ren, Qingchun
Wang, Minjun
Gao, Mingzhu
author_sort Lei, Yu
collection PubMed
description Cholesteatoma is a noncancerous cystic lesion caused by an abnormal growth of keratinizing squamous epithelium which is invasive and capable of destroying structures. A prospective study on the expression of membrane type1-matrix metalloproteinases (MMP-14) and its related influencing factors in middle ear cholesteatoma was conducted to fully understand the pathogenesis of cholesteatoma in the molecular level. We examined the expression of MMP-14 by immunohistochemical staining 39 middle ear cholesteatoma specimens and 10 external auditory meatus epithelial cell specimens. The cholesteatoma specimens were divided into 4 groups according to the degree of destruction of the ossicles during surgery. The associated factors affecting MMP-14 expression were analyzed using statistical methods; The positive expression of MMP-14 in the epithelium of the external auditory canal was significantly different between middle ear cholesteatoma and normal patients (P < .05); Gender, age, and the degree of hearing loss had no statistically significant effect on MMP-14 expression (P > .05); The expression of MMP-14 was positively correlated with the severity of bone destruction (R = 0.535, P < .05); MMP-14 plays an important role in the pathological development of the epithelium of cholesteatoma; MMP-14 expression in middle ear cholesteatoma tissue was not strongly correlated with the level of hearing loss, age or gender, but was positively correlated with the degree of middle ear bone destruction.
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spelling pubmed-106155392023-10-31 Expression of MMP-14 and its role in bone destruction in middle ear cholesteatoma: A prospective observational study Lei, Yu An, Junjun Ren, Qingchun Wang, Minjun Gao, Mingzhu Medicine (Baltimore) 6000 Cholesteatoma is a noncancerous cystic lesion caused by an abnormal growth of keratinizing squamous epithelium which is invasive and capable of destroying structures. A prospective study on the expression of membrane type1-matrix metalloproteinases (MMP-14) and its related influencing factors in middle ear cholesteatoma was conducted to fully understand the pathogenesis of cholesteatoma in the molecular level. We examined the expression of MMP-14 by immunohistochemical staining 39 middle ear cholesteatoma specimens and 10 external auditory meatus epithelial cell specimens. The cholesteatoma specimens were divided into 4 groups according to the degree of destruction of the ossicles during surgery. The associated factors affecting MMP-14 expression were analyzed using statistical methods; The positive expression of MMP-14 in the epithelium of the external auditory canal was significantly different between middle ear cholesteatoma and normal patients (P < .05); Gender, age, and the degree of hearing loss had no statistically significant effect on MMP-14 expression (P > .05); The expression of MMP-14 was positively correlated with the severity of bone destruction (R = 0.535, P < .05); MMP-14 plays an important role in the pathological development of the epithelium of cholesteatoma; MMP-14 expression in middle ear cholesteatoma tissue was not strongly correlated with the level of hearing loss, age or gender, but was positively correlated with the degree of middle ear bone destruction. Lippincott Williams & Wilkins 2023-10-27 /pmc/articles/PMC10615539/ /pubmed/37904429 http://dx.doi.org/10.1097/MD.0000000000035538 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 6000
Lei, Yu
An, Junjun
Ren, Qingchun
Wang, Minjun
Gao, Mingzhu
Expression of MMP-14 and its role in bone destruction in middle ear cholesteatoma: A prospective observational study
title Expression of MMP-14 and its role in bone destruction in middle ear cholesteatoma: A prospective observational study
title_full Expression of MMP-14 and its role in bone destruction in middle ear cholesteatoma: A prospective observational study
title_fullStr Expression of MMP-14 and its role in bone destruction in middle ear cholesteatoma: A prospective observational study
title_full_unstemmed Expression of MMP-14 and its role in bone destruction in middle ear cholesteatoma: A prospective observational study
title_short Expression of MMP-14 and its role in bone destruction in middle ear cholesteatoma: A prospective observational study
title_sort expression of mmp-14 and its role in bone destruction in middle ear cholesteatoma: a prospective observational study
topic 6000
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615539/
https://www.ncbi.nlm.nih.gov/pubmed/37904429
http://dx.doi.org/10.1097/MD.0000000000035538
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