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Use of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study
OBJECTIVE: Extremely preterm (EP) impairment rates are likely underestimated using the Bayley III norm-based thresholds scores and may be better assessed relative to concurrent healthy term reference (TR) infants born in the same hospital. STUDY DESIGN: Blinded, certified examiners in the Neonatal R...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group US
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615749/ https://www.ncbi.nlm.nih.gov/pubmed/37542155 http://dx.doi.org/10.1038/s41372-023-01729-x |
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| author | Green, Charles E. Tyson, Jon E. Heyne, Roy J. Hintz, Susan R. Vohr, Betty R. Bann, Carla M. Das, Abhik Bell, Edward F. Debsareea, Sana Boral Stephens, Emily Gantz, Marie G. Petrie Huitema, Carolyn M. Johnson, Karen J. Watterberg, Kristi L. Mosquera, Ricardo Peralta-Carcelen, Myriam Wilson-Costello, Deanne E. Colaizy, Tarah T. Maitre, Nathalie L. Merhar, Stephanie L. Adams-Chapman, Ira Fuller, Janell Hartley-McAndrew, Michelle E. Malcolm, William F. Winter, Sarah Duncan, Andrea F. Myer, Gary J. Kicklighter, Stephen D. Wyckoff, Myra H. DeMauro, Sara B. Hibbs, Anna Maria Stoll, Barbara J. Carlo, Waldemar A. Van Meurs, Krisa P. Rysavy, Matthew A. Patel, Ravi M. Sánchez, Pablo J. Laptook, Abbot R. Cotten, C. Michael D’Angio, Carl T. Walsh, Michele C. |
| author_facet | Green, Charles E. Tyson, Jon E. Heyne, Roy J. Hintz, Susan R. Vohr, Betty R. Bann, Carla M. Das, Abhik Bell, Edward F. Debsareea, Sana Boral Stephens, Emily Gantz, Marie G. Petrie Huitema, Carolyn M. Johnson, Karen J. Watterberg, Kristi L. Mosquera, Ricardo Peralta-Carcelen, Myriam Wilson-Costello, Deanne E. Colaizy, Tarah T. Maitre, Nathalie L. Merhar, Stephanie L. Adams-Chapman, Ira Fuller, Janell Hartley-McAndrew, Michelle E. Malcolm, William F. Winter, Sarah Duncan, Andrea F. Myer, Gary J. Kicklighter, Stephen D. Wyckoff, Myra H. DeMauro, Sara B. Hibbs, Anna Maria Stoll, Barbara J. Carlo, Waldemar A. Van Meurs, Krisa P. Rysavy, Matthew A. Patel, Ravi M. Sánchez, Pablo J. Laptook, Abbot R. Cotten, C. Michael D’Angio, Carl T. Walsh, Michele C. |
| author_sort | Green, Charles E. |
| collection | PubMed |
| description | OBJECTIVE: Extremely preterm (EP) impairment rates are likely underestimated using the Bayley III norm-based thresholds scores and may be better assessed relative to concurrent healthy term reference (TR) infants born in the same hospital. STUDY DESIGN: Blinded, certified examiners in the Neonatal Research Network (NRN) evaluated EP survivors and a sample of healthy TR infants recruited near the 2-year assessment age. RESULTS: We assessed 1452 EP infants and 183 TR infants. TR-based thresholds showed higher overall EP impairment than Bayley norm-based thresholds (O.R. = 1.86; [95% CI 1.56–2.23], especially for severe impairment (36% vs. 24%; p ≤ 0.001). Difficulty recruiting TR patients at 2 years extended the study by 14 months and affected their demographics. CONCLUSION: Impairment rates among EP infants appear to be substantially underestimated from Bayley III norms. These rates may be best assessed by comparison with healthy term infants followed with minimal attrition from birth in the same centers. CLINICALTRIALS.GOV ID: Term Reference (under the Generic Database Study): NCT00063063 |
| format | Online Article Text |
| id | pubmed-10615749 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Nature Publishing Group US |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-106157492023-11-01 Use of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study Green, Charles E. Tyson, Jon E. Heyne, Roy J. Hintz, Susan R. Vohr, Betty R. Bann, Carla M. Das, Abhik Bell, Edward F. Debsareea, Sana Boral Stephens, Emily Gantz, Marie G. Petrie Huitema, Carolyn M. Johnson, Karen J. Watterberg, Kristi L. Mosquera, Ricardo Peralta-Carcelen, Myriam Wilson-Costello, Deanne E. Colaizy, Tarah T. Maitre, Nathalie L. Merhar, Stephanie L. Adams-Chapman, Ira Fuller, Janell Hartley-McAndrew, Michelle E. Malcolm, William F. Winter, Sarah Duncan, Andrea F. Myer, Gary J. Kicklighter, Stephen D. Wyckoff, Myra H. DeMauro, Sara B. Hibbs, Anna Maria Stoll, Barbara J. Carlo, Waldemar A. Van Meurs, Krisa P. Rysavy, Matthew A. Patel, Ravi M. Sánchez, Pablo J. Laptook, Abbot R. Cotten, C. Michael D’Angio, Carl T. Walsh, Michele C. J Perinatol Article OBJECTIVE: Extremely preterm (EP) impairment rates are likely underestimated using the Bayley III norm-based thresholds scores and may be better assessed relative to concurrent healthy term reference (TR) infants born in the same hospital. STUDY DESIGN: Blinded, certified examiners in the Neonatal Research Network (NRN) evaluated EP survivors and a sample of healthy TR infants recruited near the 2-year assessment age. RESULTS: We assessed 1452 EP infants and 183 TR infants. TR-based thresholds showed higher overall EP impairment than Bayley norm-based thresholds (O.R. = 1.86; [95% CI 1.56–2.23], especially for severe impairment (36% vs. 24%; p ≤ 0.001). Difficulty recruiting TR patients at 2 years extended the study by 14 months and affected their demographics. CONCLUSION: Impairment rates among EP infants appear to be substantially underestimated from Bayley III norms. These rates may be best assessed by comparison with healthy term infants followed with minimal attrition from birth in the same centers. CLINICALTRIALS.GOV ID: Term Reference (under the Generic Database Study): NCT00063063 Nature Publishing Group US 2023-08-04 2023 /pmc/articles/PMC10615749/ /pubmed/37542155 http://dx.doi.org/10.1038/s41372-023-01729-x Text en © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Green, Charles E. Tyson, Jon E. Heyne, Roy J. Hintz, Susan R. Vohr, Betty R. Bann, Carla M. Das, Abhik Bell, Edward F. Debsareea, Sana Boral Stephens, Emily Gantz, Marie G. Petrie Huitema, Carolyn M. Johnson, Karen J. Watterberg, Kristi L. Mosquera, Ricardo Peralta-Carcelen, Myriam Wilson-Costello, Deanne E. Colaizy, Tarah T. Maitre, Nathalie L. Merhar, Stephanie L. Adams-Chapman, Ira Fuller, Janell Hartley-McAndrew, Michelle E. Malcolm, William F. Winter, Sarah Duncan, Andrea F. Myer, Gary J. Kicklighter, Stephen D. Wyckoff, Myra H. DeMauro, Sara B. Hibbs, Anna Maria Stoll, Barbara J. Carlo, Waldemar A. Van Meurs, Krisa P. Rysavy, Matthew A. Patel, Ravi M. Sánchez, Pablo J. Laptook, Abbot R. Cotten, C. Michael D’Angio, Carl T. Walsh, Michele C. Use of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study |
| title | Use of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study |
| title_full | Use of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study |
| title_fullStr | Use of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study |
| title_full_unstemmed | Use of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study |
| title_short | Use of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study |
| title_sort | use of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615749/ https://www.ncbi.nlm.nih.gov/pubmed/37542155 http://dx.doi.org/10.1038/s41372-023-01729-x |
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