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Comparison of nickel oxide nano and microparticles toxicity in rat liver: molecular, biochemical, and histopathological study
The unique properties of nickel oxide nanoparticles distinguish it from classical nickel compounds, increasing its use in agriculture, industry, and many industrial areas. The aim of this study is to investigate the possible toxicity of nickel oxide and nickel oxide nanoparticles in the liver. For t...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615818/ https://www.ncbi.nlm.nih.gov/pubmed/37915490 http://dx.doi.org/10.1093/toxres/tfad062 |
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author | Adiguzel, Caglar Karaboduk, Hatice Apaydin, Fatma Gokce Kalender, Suna Kalender, Yusuf |
author_facet | Adiguzel, Caglar Karaboduk, Hatice Apaydin, Fatma Gokce Kalender, Suna Kalender, Yusuf |
author_sort | Adiguzel, Caglar |
collection | PubMed |
description | The unique properties of nickel oxide nanoparticles distinguish it from classical nickel compounds, increasing its use in agriculture, industry, and many industrial areas. The aim of this study is to investigate the possible toxicity of nickel oxide and nickel oxide nanoparticles in the liver. For this purpose, Wistar rats were given nickel oxide and nickel oxide nanoparticles orally, intraperitoneally, and intravenously for 21 days. Liver organ weight, biochemical and hematological parameters, oxidative stress (malondialdehyde, catalase, superoxide dismutase, glutathione peroxidase, and glutathione S transferase), acetylcholinesterase activities, inflammation levels, apoptotic markers, and histopathological changes were evaluated comparatively. When the data obtained were examined in general, it was observed that nickel oxide nanoparticles caused more hepatotoxicity in liver tissue than nickel oxide in terms of oxidative stress parameters, apoptotic markers, inflammation indicators, and other parameters examined. The results suggest that toxicity induced by both nickel oxide and nickel oxide nanoparticles plays an important role in hepatocyte apoptosis. |
format | Online Article Text |
id | pubmed-10615818 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-106158182023-11-01 Comparison of nickel oxide nano and microparticles toxicity in rat liver: molecular, biochemical, and histopathological study Adiguzel, Caglar Karaboduk, Hatice Apaydin, Fatma Gokce Kalender, Suna Kalender, Yusuf Toxicol Res (Camb) Paper The unique properties of nickel oxide nanoparticles distinguish it from classical nickel compounds, increasing its use in agriculture, industry, and many industrial areas. The aim of this study is to investigate the possible toxicity of nickel oxide and nickel oxide nanoparticles in the liver. For this purpose, Wistar rats were given nickel oxide and nickel oxide nanoparticles orally, intraperitoneally, and intravenously for 21 days. Liver organ weight, biochemical and hematological parameters, oxidative stress (malondialdehyde, catalase, superoxide dismutase, glutathione peroxidase, and glutathione S transferase), acetylcholinesterase activities, inflammation levels, apoptotic markers, and histopathological changes were evaluated comparatively. When the data obtained were examined in general, it was observed that nickel oxide nanoparticles caused more hepatotoxicity in liver tissue than nickel oxide in terms of oxidative stress parameters, apoptotic markers, inflammation indicators, and other parameters examined. The results suggest that toxicity induced by both nickel oxide and nickel oxide nanoparticles plays an important role in hepatocyte apoptosis. Oxford University Press 2023-08-01 /pmc/articles/PMC10615818/ /pubmed/37915490 http://dx.doi.org/10.1093/toxres/tfad062 Text en © The Author(s) 2023. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Paper Adiguzel, Caglar Karaboduk, Hatice Apaydin, Fatma Gokce Kalender, Suna Kalender, Yusuf Comparison of nickel oxide nano and microparticles toxicity in rat liver: molecular, biochemical, and histopathological study |
title | Comparison of nickel oxide nano and microparticles toxicity in rat liver: molecular, biochemical, and histopathological study |
title_full | Comparison of nickel oxide nano and microparticles toxicity in rat liver: molecular, biochemical, and histopathological study |
title_fullStr | Comparison of nickel oxide nano and microparticles toxicity in rat liver: molecular, biochemical, and histopathological study |
title_full_unstemmed | Comparison of nickel oxide nano and microparticles toxicity in rat liver: molecular, biochemical, and histopathological study |
title_short | Comparison of nickel oxide nano and microparticles toxicity in rat liver: molecular, biochemical, and histopathological study |
title_sort | comparison of nickel oxide nano and microparticles toxicity in rat liver: molecular, biochemical, and histopathological study |
topic | Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615818/ https://www.ncbi.nlm.nih.gov/pubmed/37915490 http://dx.doi.org/10.1093/toxres/tfad062 |
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