Injury primes mutation-bearing astrocytes for dedifferentiation in later life

Despite their latent neurogenic potential, most normal parenchymal astrocytes fail to dedifferentiate to neural stem cells in response to injury. In contrast, aberrant lineage plasticity is a hallmark of gliomas, and this suggests that tumor suppressors may constrain astrocyte dedifferentiation. Her...

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Detalles Bibliográficos
Autores principales: Simpson Ragdale, Holly, Clements, Melanie, Tang, Wenhao, Deltcheva, Elitza, Andreassi, Catia, Lai, Alvina G., Chang, Wai Hoong, Pandrea, Maria, Andrew, Ivan, Game, Laurence, Uddin, Imran, Ellis, Michael, Enver, Tariq, Riccio, Antonella, Marguerat, Samuel, Parrinello, Simona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615847/
https://www.ncbi.nlm.nih.gov/pubmed/36841240
http://dx.doi.org/10.1016/j.cub.2023.02.013

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