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A history of asthma is associated with susceptibility to hidradenitis suppurativa: a population-based longitudinal study

The association of hidradenitis suppurativa (HS) and asthma remains to be investigated. To assess the bidirectional association between HS and asthma. A population-based study was conducted to compare HS patients (n = 6779) with age-, sex-, and ethnicity-matched control subjects (n = 33,259) with re...

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Autores principales: Kridin, Khalaf, Shihade, Wesal, Weinstein, Orly, Zoller, Lilach, Onn, Erez, Cohen, Arnon, Solomon-Cohen, Efrat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615903/
https://www.ncbi.nlm.nih.gov/pubmed/37642698
http://dx.doi.org/10.1007/s00403-023-02693-4
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author Kridin, Khalaf
Shihade, Wesal
Weinstein, Orly
Zoller, Lilach
Onn, Erez
Cohen, Arnon
Solomon-Cohen, Efrat
author_facet Kridin, Khalaf
Shihade, Wesal
Weinstein, Orly
Zoller, Lilach
Onn, Erez
Cohen, Arnon
Solomon-Cohen, Efrat
author_sort Kridin, Khalaf
collection PubMed
description The association of hidradenitis suppurativa (HS) and asthma remains to be investigated. To assess the bidirectional association between HS and asthma. A population-based study was conducted to compare HS patients (n = 6779) with age-, sex-, and ethnicity-matched control subjects (n = 33,259) with regard to the incidence of new onset and the prevalence of preexisting asthma. Adjusted hazard ratios (HRs) and adjusted odds ratios (ORs) were calculated. The prevalence of preexisting asthma was higher in patients with HS relative to controls (9.6% vs. 6.9%, respectively; P < 0.001). The odds of HS were 1.4-fold greater in patients with a history of asthma (fully adjusted OR 1.41; 95% CI 1.27–1.55; P < 0.001). The incidence rate of new-onset asthma was estimated at 9.0 (95% CI 6.3–12.7) and 6.2 (95% CI 5.1–7.5) cases per 10,000 person-years among patients with HS and controls, respectively. The risk of asthma was not statistically different in patients with HS and controls (fully adjusted HR 1.53; 95% CI 0.98–2.38; P = 0.062). Relative to other patients with HS, those with HS and comorbid asthma were younger at the onset of HS (30.7 [14.7] vs. 33.3 [15.1], respectively; P < 0.001) and had a comparable risk of all-cause mortality (adjusted HR 0.86; 95% CI 0.44–1.68; P = 0.660). A history of asthma confers susceptibility to subsequent development of HS. This observation is of importance for clinicians managing both patients with HS and asthma. Further research is warranted to elucidate the pathomechanism underlying this finding. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00403-023-02693-4.
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spelling pubmed-106159032023-11-01 A history of asthma is associated with susceptibility to hidradenitis suppurativa: a population-based longitudinal study Kridin, Khalaf Shihade, Wesal Weinstein, Orly Zoller, Lilach Onn, Erez Cohen, Arnon Solomon-Cohen, Efrat Arch Dermatol Res Original Paper The association of hidradenitis suppurativa (HS) and asthma remains to be investigated. To assess the bidirectional association between HS and asthma. A population-based study was conducted to compare HS patients (n = 6779) with age-, sex-, and ethnicity-matched control subjects (n = 33,259) with regard to the incidence of new onset and the prevalence of preexisting asthma. Adjusted hazard ratios (HRs) and adjusted odds ratios (ORs) were calculated. The prevalence of preexisting asthma was higher in patients with HS relative to controls (9.6% vs. 6.9%, respectively; P < 0.001). The odds of HS were 1.4-fold greater in patients with a history of asthma (fully adjusted OR 1.41; 95% CI 1.27–1.55; P < 0.001). The incidence rate of new-onset asthma was estimated at 9.0 (95% CI 6.3–12.7) and 6.2 (95% CI 5.1–7.5) cases per 10,000 person-years among patients with HS and controls, respectively. The risk of asthma was not statistically different in patients with HS and controls (fully adjusted HR 1.53; 95% CI 0.98–2.38; P = 0.062). Relative to other patients with HS, those with HS and comorbid asthma were younger at the onset of HS (30.7 [14.7] vs. 33.3 [15.1], respectively; P < 0.001) and had a comparable risk of all-cause mortality (adjusted HR 0.86; 95% CI 0.44–1.68; P = 0.660). A history of asthma confers susceptibility to subsequent development of HS. This observation is of importance for clinicians managing both patients with HS and asthma. Further research is warranted to elucidate the pathomechanism underlying this finding. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00403-023-02693-4. Springer Berlin Heidelberg 2023-08-29 2023 /pmc/articles/PMC10615903/ /pubmed/37642698 http://dx.doi.org/10.1007/s00403-023-02693-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Paper
Kridin, Khalaf
Shihade, Wesal
Weinstein, Orly
Zoller, Lilach
Onn, Erez
Cohen, Arnon
Solomon-Cohen, Efrat
A history of asthma is associated with susceptibility to hidradenitis suppurativa: a population-based longitudinal study
title A history of asthma is associated with susceptibility to hidradenitis suppurativa: a population-based longitudinal study
title_full A history of asthma is associated with susceptibility to hidradenitis suppurativa: a population-based longitudinal study
title_fullStr A history of asthma is associated with susceptibility to hidradenitis suppurativa: a population-based longitudinal study
title_full_unstemmed A history of asthma is associated with susceptibility to hidradenitis suppurativa: a population-based longitudinal study
title_short A history of asthma is associated with susceptibility to hidradenitis suppurativa: a population-based longitudinal study
title_sort history of asthma is associated with susceptibility to hidradenitis suppurativa: a population-based longitudinal study
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615903/
https://www.ncbi.nlm.nih.gov/pubmed/37642698
http://dx.doi.org/10.1007/s00403-023-02693-4
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