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Immunoception: the insular cortex perspective
To define the systemic neuroimmune interactions in health and disease, we recently suggested immunoception as a term that refers to the existence of bidirectional functional loops between the brain and the immune system. This concept suggests that the brain constantly monitors changes in immune acti...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616063/ https://www.ncbi.nlm.nih.gov/pubmed/37386172 http://dx.doi.org/10.1038/s41423-023-01051-8 |
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author | Rolls, Asya |
author_facet | Rolls, Asya |
author_sort | Rolls, Asya |
collection | PubMed |
description | To define the systemic neuroimmune interactions in health and disease, we recently suggested immunoception as a term that refers to the existence of bidirectional functional loops between the brain and the immune system. This concept suggests that the brain constantly monitors changes in immune activity and, in turn, can regulate the immune system to generate a physiologically synchronized response. Therefore, the brain has to represent information regarding the state of the immune system, which can occure in multiple ways. One such representation is an immunengram, a trace that is partially stored by neurons and partially by the local tissue. This review will discuss our current understanding of immunoception and immunengrams, focusing on their manifestation in a specific brain region, the insular cortex (IC). |
format | Online Article Text |
id | pubmed-10616063 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-106160632023-11-01 Immunoception: the insular cortex perspective Rolls, Asya Cell Mol Immunol Review Article To define the systemic neuroimmune interactions in health and disease, we recently suggested immunoception as a term that refers to the existence of bidirectional functional loops between the brain and the immune system. This concept suggests that the brain constantly monitors changes in immune activity and, in turn, can regulate the immune system to generate a physiologically synchronized response. Therefore, the brain has to represent information regarding the state of the immune system, which can occure in multiple ways. One such representation is an immunengram, a trace that is partially stored by neurons and partially by the local tissue. This review will discuss our current understanding of immunoception and immunengrams, focusing on their manifestation in a specific brain region, the insular cortex (IC). Nature Publishing Group UK 2023-06-29 2023-11 /pmc/articles/PMC10616063/ /pubmed/37386172 http://dx.doi.org/10.1038/s41423-023-01051-8 Text en © The Author(s), under exclusive licence to CSI and USTC 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Article Rolls, Asya Immunoception: the insular cortex perspective |
title | Immunoception: the insular cortex perspective |
title_full | Immunoception: the insular cortex perspective |
title_fullStr | Immunoception: the insular cortex perspective |
title_full_unstemmed | Immunoception: the insular cortex perspective |
title_short | Immunoception: the insular cortex perspective |
title_sort | immunoception: the insular cortex perspective |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616063/ https://www.ncbi.nlm.nih.gov/pubmed/37386172 http://dx.doi.org/10.1038/s41423-023-01051-8 |
work_keys_str_mv | AT rollsasya immunoceptiontheinsularcortexperspective |