eQTL mapping in fetal-like pancreatic progenitor cells reveals early developmental insights into diabetes risk

The impact of genetic regulatory variation active in early pancreatic development on adult pancreatic disease and traits is not well understood. Here, we generate a panel of 107 fetal-like iPSC-derived pancreatic progenitor cells (iPSC-PPCs) from whole genome-sequenced individuals and identify 4065...

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Detalles Bibliográficos
Autores principales: Nguyen, Jennifer P., Arthur, Timothy D., Fujita, Kyohei, Salgado, Bianca M., Donovan, Margaret K. R., Matsui, Hiroko, Kim, Ji Hyun, D’Antonio-Chronowska, Agnieszka, D’Antonio, Matteo, Frazer, Kelly A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616100/
https://www.ncbi.nlm.nih.gov/pubmed/37903777
http://dx.doi.org/10.1038/s41467-023-42560-4

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