Microglia-mediated demyelination protects against CD8(+) T cell-driven axon degeneration in mice carrying PLP defects

Axon degeneration and functional decline in myelin diseases are often attributed to loss of myelin but their relation is not fully understood. Perturbed myelinating glia can instigate chronic neuroinflammation and contribute to demyelination and axonal damage. Here we study mice with distinct defect...

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Detalles Bibliográficos
Autores principales: Groh, Janos, Abdelwahab, Tassnim, Kattimani, Yogita, Hörner, Michaela, Loserth, Silke, Gudi, Viktoria, Adalbert, Robert, Imdahl, Fabian, Saliba, Antoine-Emmanuel, Coleman, Michael, Stangel, Martin, Simons, Mikael, Martini, Rudolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616105/
https://www.ncbi.nlm.nih.gov/pubmed/37903797
http://dx.doi.org/10.1038/s41467-023-42570-2

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