An apical Phe-His pair defines the Orai1-coupling site and its occlusion within STIM1

Ca(2+) signal-generation through inter-membrane junctional coupling between endoplasmic reticulum (ER) STIM proteins and plasma membrane (PM) Orai channels, remains a vital but undefined mechanism. We identify two unusual overlapping Phe-His aromatic pairs within the STIM1 apical helix, one of which...

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Detalles Bibliográficos
Autores principales: Zhou, Yandong, Jennette, Michelle R., Ma, Guolin, Kazzaz, Sarah A., Baraniak, James H., Nwokonko, Robert M., Groff, Mallary L., Velasquez-Reynel, Marcela, Huang, Yun, Wang, Youjun, Gill, Donald L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616141/
https://www.ncbi.nlm.nih.gov/pubmed/37903816
http://dx.doi.org/10.1038/s41467-023-42254-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616141/
https://www.ncbi.nlm.nih.gov/pubmed/37903816
http://dx.doi.org/10.1038/s41467-023-42254-x

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