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An apical Phe-His pair defines the Orai1-coupling site and its occlusion within STIM1
Ca(2+) signal-generation through inter-membrane junctional coupling between endoplasmic reticulum (ER) STIM proteins and plasma membrane (PM) Orai channels, remains a vital but undefined mechanism. We identify two unusual overlapping Phe-His aromatic pairs within the STIM1 apical helix, one of which...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616141/ https://www.ncbi.nlm.nih.gov/pubmed/37903816 http://dx.doi.org/10.1038/s41467-023-42254-x |