Talin-1 inhibits Smurf1-mediated Stat3 degradation to modulate β-cell proliferation and mass in mice

Insufficient pancreatic β-cell mass and reduced insulin expression are key events in the pathogenesis of diabetes mellitus (DM). Here we demonstrate the high expression of Talin-1 in β-cells and that deficiency of Talin-1 reduces β-cell proliferation, which leads to reduced β-cell mass and insulin e...

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Detalles Bibliográficos
Autores principales: Hou, Xiaoting, Chen, Yangshan, Zhou, Bo, Tang, Wanze, Ding, Zhen, Chen, Litong, Wu, Yun, Yang, Hongyu, Du, Changzheng, Yang, Dazhi, Ma, Guixing, Cao, Huiling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616178/
https://www.ncbi.nlm.nih.gov/pubmed/37903776
http://dx.doi.org/10.1038/s41419-023-06235-8

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