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Alterations of neural activity in the prefrontal cortex associated with deficits in working memory performance
Working memory (WM), a core cognitive function, enables the temporary holding and manipulation of information in mind to support ongoing behavior. Neurophysiological recordings conducted in nonhuman primates have revealed neural correlates of this process in a network of higher-order cortical region...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616307/ https://www.ncbi.nlm.nih.gov/pubmed/37915531 http://dx.doi.org/10.3389/fnbeh.2023.1213435 |
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author | Li, Sihai Rosen, Matthew C. Chang, Suha David, Samuel Freedman, David J. |
author_facet | Li, Sihai Rosen, Matthew C. Chang, Suha David, Samuel Freedman, David J. |
author_sort | Li, Sihai |
collection | PubMed |
description | Working memory (WM), a core cognitive function, enables the temporary holding and manipulation of information in mind to support ongoing behavior. Neurophysiological recordings conducted in nonhuman primates have revealed neural correlates of this process in a network of higher-order cortical regions, particularly the prefrontal cortex (PFC). Here, we review the circuit mechanisms and functional importance of WM-related activity in these areas. Recent neurophysiological data indicates that the absence of these neural correlates at different stages of WM is accompanied by distinct behavioral deficits, which are characteristic of various disease states/normal aging and which we review here. Finally, we discuss emerging evidence of electrical stimulation ameliorating these WM deficits in both humans and non-human primates. These results are important for a basic understanding of the neural mechanisms supporting WM, as well as for translational efforts to developing therapies capable of enhancing healthy WM ability or restoring WM from dysfunction. |
format | Online Article Text |
id | pubmed-10616307 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106163072023-11-01 Alterations of neural activity in the prefrontal cortex associated with deficits in working memory performance Li, Sihai Rosen, Matthew C. Chang, Suha David, Samuel Freedman, David J. Front Behav Neurosci Behavioral Neuroscience Working memory (WM), a core cognitive function, enables the temporary holding and manipulation of information in mind to support ongoing behavior. Neurophysiological recordings conducted in nonhuman primates have revealed neural correlates of this process in a network of higher-order cortical regions, particularly the prefrontal cortex (PFC). Here, we review the circuit mechanisms and functional importance of WM-related activity in these areas. Recent neurophysiological data indicates that the absence of these neural correlates at different stages of WM is accompanied by distinct behavioral deficits, which are characteristic of various disease states/normal aging and which we review here. Finally, we discuss emerging evidence of electrical stimulation ameliorating these WM deficits in both humans and non-human primates. These results are important for a basic understanding of the neural mechanisms supporting WM, as well as for translational efforts to developing therapies capable of enhancing healthy WM ability or restoring WM from dysfunction. Frontiers Media S.A. 2023-10-17 /pmc/articles/PMC10616307/ /pubmed/37915531 http://dx.doi.org/10.3389/fnbeh.2023.1213435 Text en Copyright © 2023 Li, Rosen, Chang, David and Freedman. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Behavioral Neuroscience Li, Sihai Rosen, Matthew C. Chang, Suha David, Samuel Freedman, David J. Alterations of neural activity in the prefrontal cortex associated with deficits in working memory performance |
title | Alterations of neural activity in the prefrontal cortex associated with deficits in working memory performance |
title_full | Alterations of neural activity in the prefrontal cortex associated with deficits in working memory performance |
title_fullStr | Alterations of neural activity in the prefrontal cortex associated with deficits in working memory performance |
title_full_unstemmed | Alterations of neural activity in the prefrontal cortex associated with deficits in working memory performance |
title_short | Alterations of neural activity in the prefrontal cortex associated with deficits in working memory performance |
title_sort | alterations of neural activity in the prefrontal cortex associated with deficits in working memory performance |
topic | Behavioral Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616307/ https://www.ncbi.nlm.nih.gov/pubmed/37915531 http://dx.doi.org/10.3389/fnbeh.2023.1213435 |
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