Peritoneal-directed chimeric oncolytic virus CF17 prevents malignant ascites and improves survival in gastric cancer peritoneal metastases

Gastric cancer (GC) peritoneal metastasis (PM) is fatal without effective therapy. We investigated CF17, a new replication-competent chimeric poxvirus, against GC cell lines in vitro and PM in an aggressive GCPM mouse model. We performed viral proliferation and cytotoxicity assays on intestinal-type...

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Detalles Bibliográficos
Autores principales: Yang, Annie, Zhang, Zhifang, Chaurasiya, Shyambabu, Park, Anthony K., Lu, Jianming, Kim, Sang-In, Valencia, Hannah, Fong, Yuman, Woo, Yanghee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616379/
https://www.ncbi.nlm.nih.gov/pubmed/37915757
http://dx.doi.org/10.1016/j.omto.2023.100734

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