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Approach to Pregnancy in Patients With Lupus Nephritis

Active lupus nephritis (LN) in pregnancy is strongly associated with poor maternal and fetal outcomes and, therefore, has implications on the planning, timing, and management. Prepregnancy evaluation is essential for all LN patients with childbearing potential to ensure pregnancies proceed in a safe...

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Autores principales: Tan, Benjamin, So, Paolo Nikolai, Krishnan, Anoushka, Carriazo, Sol, Bahamonde, Josélyn Reyes, Lamech, Tanuj Moses, Hassanein, Mohamed, Lerma, Edgar, Wiegley, Nasim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616386/
https://www.ncbi.nlm.nih.gov/pubmed/37915962
http://dx.doi.org/10.1016/j.xkme.2023.100724
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author Tan, Benjamin
So, Paolo Nikolai
Krishnan, Anoushka
Carriazo, Sol
Bahamonde, Josélyn Reyes
Lamech, Tanuj Moses
Hassanein, Mohamed
Lerma, Edgar
Wiegley, Nasim
author_facet Tan, Benjamin
So, Paolo Nikolai
Krishnan, Anoushka
Carriazo, Sol
Bahamonde, Josélyn Reyes
Lamech, Tanuj Moses
Hassanein, Mohamed
Lerma, Edgar
Wiegley, Nasim
author_sort Tan, Benjamin
collection PubMed
description Active lupus nephritis (LN) in pregnancy is strongly associated with poor maternal and fetal outcomes and, therefore, has implications on the planning, timing, and management. Prepregnancy evaluation is essential for all LN patients with childbearing potential to ensure pregnancies proceed in a safe and timely manner. Both maternal and fetal risks are communicated to patient during the evaluation. Stratification into different risk profile groups is then made based on disease activity and organ impairment severity. Patients with LN are generally divided into 3 main groups. Patients with LN who become pregnant receive treatments that are nonteratogenic and optimal for fetal and maternal outcomes. Throughout the pregnancy period, these patients are monitored closely under surveillance by a multidisciplinary team of clinicians. The management of patients with LN in pregnancy can be challenging both diagnostically (distinguishing LN from pre-eclampsia and determining the role and timing of kidney biopsy) and therapeutically (LN flares during pregnancy and managing a newly diagnosed LN during pregnancy).
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spelling pubmed-106163862023-11-01 Approach to Pregnancy in Patients With Lupus Nephritis Tan, Benjamin So, Paolo Nikolai Krishnan, Anoushka Carriazo, Sol Bahamonde, Josélyn Reyes Lamech, Tanuj Moses Hassanein, Mohamed Lerma, Edgar Wiegley, Nasim Kidney Med GlomCon Mini Review Active lupus nephritis (LN) in pregnancy is strongly associated with poor maternal and fetal outcomes and, therefore, has implications on the planning, timing, and management. Prepregnancy evaluation is essential for all LN patients with childbearing potential to ensure pregnancies proceed in a safe and timely manner. Both maternal and fetal risks are communicated to patient during the evaluation. Stratification into different risk profile groups is then made based on disease activity and organ impairment severity. Patients with LN are generally divided into 3 main groups. Patients with LN who become pregnant receive treatments that are nonteratogenic and optimal for fetal and maternal outcomes. Throughout the pregnancy period, these patients are monitored closely under surveillance by a multidisciplinary team of clinicians. The management of patients with LN in pregnancy can be challenging both diagnostically (distinguishing LN from pre-eclampsia and determining the role and timing of kidney biopsy) and therapeutically (LN flares during pregnancy and managing a newly diagnosed LN during pregnancy). Elsevier 2023-09-17 /pmc/articles/PMC10616386/ /pubmed/37915962 http://dx.doi.org/10.1016/j.xkme.2023.100724 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle GlomCon Mini Review
Tan, Benjamin
So, Paolo Nikolai
Krishnan, Anoushka
Carriazo, Sol
Bahamonde, Josélyn Reyes
Lamech, Tanuj Moses
Hassanein, Mohamed
Lerma, Edgar
Wiegley, Nasim
Approach to Pregnancy in Patients With Lupus Nephritis
title Approach to Pregnancy in Patients With Lupus Nephritis
title_full Approach to Pregnancy in Patients With Lupus Nephritis
title_fullStr Approach to Pregnancy in Patients With Lupus Nephritis
title_full_unstemmed Approach to Pregnancy in Patients With Lupus Nephritis
title_short Approach to Pregnancy in Patients With Lupus Nephritis
title_sort approach to pregnancy in patients with lupus nephritis
topic GlomCon Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616386/
https://www.ncbi.nlm.nih.gov/pubmed/37915962
http://dx.doi.org/10.1016/j.xkme.2023.100724
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