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Reactive oxygen species drive foraging decisions in Caenorhabditis elegans
Environmental surveillance-mediated behavior integrates multiple cues through complex signaling mechanisms. In Caenorhabditis elegans, neurons coordinate perception and response through evolutionarily conserved molecular signaling cascades to mediate attraction and avoidance behaviors. However, desp...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616421/ https://www.ncbi.nlm.nih.gov/pubmed/37864874 http://dx.doi.org/10.1016/j.redox.2023.102934 |
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author | Bischer, Andrew P. Baran, Timothy M. Wojtovich, Andrew P. |
author_facet | Bischer, Andrew P. Baran, Timothy M. Wojtovich, Andrew P. |
author_sort | Bischer, Andrew P. |
collection | PubMed |
description | Environmental surveillance-mediated behavior integrates multiple cues through complex signaling mechanisms. In Caenorhabditis elegans, neurons coordinate perception and response through evolutionarily conserved molecular signaling cascades to mediate attraction and avoidance behaviors. However, despite lacking eyes, C. elegans was recently reported to perceive and react to the color blue. Here, we provide an explanation for this apparent color perception. We show that internally-generated reactive oxygen species (ROS) occurring in response to light are additive to exogenous sources of ROS, such as bacterial toxins or photosensitizers. Multiple sub-threshold sources of ROS are integrated to coordinate behavioral responses to the environment with internal physiologic cues, independent of color. We further demonstrate that avoidance behavior can be blocked by antioxidants, while ROS is both sufficient and scalable to phenocopy the avoidance response. Moreover, avoidance behavior in response to ROS is plastic and reversible, suggesting it may occur through a post-translation redox modification. Blue light affects C. elegans behavior through ROS generation by endogenous flavins in a process requiring the neuronal gustatory photoreceptor like protein, LITE-1. Our results demonstrate that LITE-1 is also required for ROS-mediated avoidance of pyocyanin and light-activated photosensitizers and this role is mediated through the modification of Cys44. Overall, these findings demonstrate that ROS and LITE-1 are central mediators of C. elegans foraging behavior through integration of multiple inputs, including light. |
format | Online Article Text |
id | pubmed-10616421 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-106164212023-11-01 Reactive oxygen species drive foraging decisions in Caenorhabditis elegans Bischer, Andrew P. Baran, Timothy M. Wojtovich, Andrew P. Redox Biol Research Paper Environmental surveillance-mediated behavior integrates multiple cues through complex signaling mechanisms. In Caenorhabditis elegans, neurons coordinate perception and response through evolutionarily conserved molecular signaling cascades to mediate attraction and avoidance behaviors. However, despite lacking eyes, C. elegans was recently reported to perceive and react to the color blue. Here, we provide an explanation for this apparent color perception. We show that internally-generated reactive oxygen species (ROS) occurring in response to light are additive to exogenous sources of ROS, such as bacterial toxins or photosensitizers. Multiple sub-threshold sources of ROS are integrated to coordinate behavioral responses to the environment with internal physiologic cues, independent of color. We further demonstrate that avoidance behavior can be blocked by antioxidants, while ROS is both sufficient and scalable to phenocopy the avoidance response. Moreover, avoidance behavior in response to ROS is plastic and reversible, suggesting it may occur through a post-translation redox modification. Blue light affects C. elegans behavior through ROS generation by endogenous flavins in a process requiring the neuronal gustatory photoreceptor like protein, LITE-1. Our results demonstrate that LITE-1 is also required for ROS-mediated avoidance of pyocyanin and light-activated photosensitizers and this role is mediated through the modification of Cys44. Overall, these findings demonstrate that ROS and LITE-1 are central mediators of C. elegans foraging behavior through integration of multiple inputs, including light. Elsevier 2023-10-13 /pmc/articles/PMC10616421/ /pubmed/37864874 http://dx.doi.org/10.1016/j.redox.2023.102934 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Paper Bischer, Andrew P. Baran, Timothy M. Wojtovich, Andrew P. Reactive oxygen species drive foraging decisions in Caenorhabditis elegans |
title | Reactive oxygen species drive foraging decisions in Caenorhabditis elegans |
title_full | Reactive oxygen species drive foraging decisions in Caenorhabditis elegans |
title_fullStr | Reactive oxygen species drive foraging decisions in Caenorhabditis elegans |
title_full_unstemmed | Reactive oxygen species drive foraging decisions in Caenorhabditis elegans |
title_short | Reactive oxygen species drive foraging decisions in Caenorhabditis elegans |
title_sort | reactive oxygen species drive foraging decisions in caenorhabditis elegans |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616421/ https://www.ncbi.nlm.nih.gov/pubmed/37864874 http://dx.doi.org/10.1016/j.redox.2023.102934 |
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