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The potential association between influenza vaccination and lower incidence of renal cell carcinoma

It is well-established that kidney cancer or renal cell carcinoma (RCC) occurs more commonly in chronic kidney disease (CKD) than in the general population, although the underlying mechanisms are incompletely understood. Beyond hereditary RCC syndromes; smoking, obesity and hypertension are widely k...

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Detalles Bibliográficos
Autores principales: Marques da Silva, Bernardo, Mayne, Kaitlin J, Zakrocka, Izabela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616471/
https://www.ncbi.nlm.nih.gov/pubmed/37915932
http://dx.doi.org/10.1093/ckj/sfad180
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author Marques da Silva, Bernardo
Mayne, Kaitlin J
Zakrocka, Izabela
author_facet Marques da Silva, Bernardo
Mayne, Kaitlin J
Zakrocka, Izabela
author_sort Marques da Silva, Bernardo
collection PubMed
description It is well-established that kidney cancer or renal cell carcinoma (RCC) occurs more commonly in chronic kidney disease (CKD) than in the general population, although the underlying mechanisms are incompletely understood. Beyond hereditary RCC syndromes; smoking, obesity and hypertension are widely known risk factors for RCC, irrespective of CKD. Kidney-specific factors such as episodes of acute kidney injury, nephrolithiasis and cyst formation have also been shown to be associated with RCC development. One potential and less explored factor is the role of viruses in the development of kidney cancer. In this issue of Clinical Kidney Journal, Lin et al. raise the interesting hypothesis that influenza vaccination may be associated with lower incidence of RCC in adults with CKD. We discuss potential mechanisms underlying this interesting observation in the context of immune dysregulation in CKD.
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spelling pubmed-106164712023-11-01 The potential association between influenza vaccination and lower incidence of renal cell carcinoma Marques da Silva, Bernardo Mayne, Kaitlin J Zakrocka, Izabela Clin Kidney J Editorial Comment It is well-established that kidney cancer or renal cell carcinoma (RCC) occurs more commonly in chronic kidney disease (CKD) than in the general population, although the underlying mechanisms are incompletely understood. Beyond hereditary RCC syndromes; smoking, obesity and hypertension are widely known risk factors for RCC, irrespective of CKD. Kidney-specific factors such as episodes of acute kidney injury, nephrolithiasis and cyst formation have also been shown to be associated with RCC development. One potential and less explored factor is the role of viruses in the development of kidney cancer. In this issue of Clinical Kidney Journal, Lin et al. raise the interesting hypothesis that influenza vaccination may be associated with lower incidence of RCC in adults with CKD. We discuss potential mechanisms underlying this interesting observation in the context of immune dysregulation in CKD. Oxford University Press 2023-07-19 /pmc/articles/PMC10616471/ /pubmed/37915932 http://dx.doi.org/10.1093/ckj/sfad180 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of the ERA. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Editorial Comment
Marques da Silva, Bernardo
Mayne, Kaitlin J
Zakrocka, Izabela
The potential association between influenza vaccination and lower incidence of renal cell carcinoma
title The potential association between influenza vaccination and lower incidence of renal cell carcinoma
title_full The potential association between influenza vaccination and lower incidence of renal cell carcinoma
title_fullStr The potential association between influenza vaccination and lower incidence of renal cell carcinoma
title_full_unstemmed The potential association between influenza vaccination and lower incidence of renal cell carcinoma
title_short The potential association between influenza vaccination and lower incidence of renal cell carcinoma
title_sort potential association between influenza vaccination and lower incidence of renal cell carcinoma
topic Editorial Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616471/
https://www.ncbi.nlm.nih.gov/pubmed/37915932
http://dx.doi.org/10.1093/ckj/sfad180
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