Protein Kinase Signaling Networks Driven by Oncogenic Gq/11 in Uveal Melanoma Identified by Phosphoproteomic and Bioinformatic Analyses

Metastatic uveal melanoma (UM) patients typically survive only 2 to 3 years because effective therapy does not yet exist. Here, to facilitate the discovery of therapeutic targets in UM, we have identified protein kinase signaling mechanisms elicited by the drivers in 90% of UM tumors: mutant constit...

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Detalles Bibliográficos
Autores principales: Onken, Michael D., Erdmann-Gilmore, Petra, Zhang, Qiang, Thapa, Kisan, King, Emily, Kaltenbronn, Kevin M., Noda, Sarah E., Makepeace, Carol M., Goldfarb, Dennis, Babur, Özgün, Townsend, R. Reid, Blumer, Kendall J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616553/
https://www.ncbi.nlm.nih.gov/pubmed/37730182
http://dx.doi.org/10.1016/j.mcpro.2023.100649

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