Inhibiting Wnt Signaling Reduces Cholestatic Injury by Disrupting the Inflammatory Axis

BACKGROUND & AIMS: β-Catenin, the effector molecule of the Wnt signaling pathway, has been shown to play a crucial role in bile acid homeostasis through direct inhibition of farnesoid X receptor (FXR), which has pleiotropic effects on bile acid homeostasis. We hypothesize that simultaneous suppr...

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Detalles Bibliográficos
Autores principales: Ayers, Mary, Kosar, Karis, Xue, Yuhua, Goel, Chhavi, Carson, Matthew, Lee, Elizabeth, Liu, Silvia, Brooks, Eva, Cornuet, Pamela, Oertel, Michael, Bhushan, Bharat, Nejak-Bowen, Kari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616556/
https://www.ncbi.nlm.nih.gov/pubmed/37579970
http://dx.doi.org/10.1016/j.jcmgh.2023.08.004

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