Membrane anchoring of the DIRAS3 N-terminal extension permits tumor suppressor function

DIRAS3 is an imprinted tumor suppressor gene encoding a GTPase that has a distinctive N-terminal extension (NTE) not found in other RAS proteins. This NTE and the prenylated C-terminus are required for DIRAS3-mediated inhibition of RAS/MAP signaling and PI3K activity at the plasma membrane. In this...

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Detalles Bibliográficos
Autores principales: Liang, Xiaowen, Jung, Sung Yun, Fong, Lon Wolf, Bildik, Gamze, Gray, Joshua P., Mao, Weiqun, Zhang, Shuxing, Millward, Steven W., Gorfe, Alemayehu A., Zhou, Yong, Lu, Zhen, Bast, Robert C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616557/
https://www.ncbi.nlm.nih.gov/pubmed/37915607
http://dx.doi.org/10.1016/j.isci.2023.108151

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