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PAEDIATRIC-11 EPIDEMIOLOGY OF PINEALOBLASTOMA IN CAPE TOWN, SOUTH AFRICA

OBJECTIVE: To compare the experience with pinealoblastoma (PB) of the neuro-oncology services of the University of Cape Town to the WHO 2021 classification. METHODS: A retrospective analysis was performed on folders of patients diagnosed at Red Cross War Memorial Children’s Hospital and Groote Schuu...

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Autores principales: Davidson, Alan, Ohonba, Efosa, Parkes, Jeannette, Pillay, Komala, Figaji, Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616585/
http://dx.doi.org/10.1093/noajnl/vdad121.043
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author Davidson, Alan
Ohonba, Efosa
Parkes, Jeannette
Pillay, Komala
Figaji, Anthony
author_facet Davidson, Alan
Ohonba, Efosa
Parkes, Jeannette
Pillay, Komala
Figaji, Anthony
author_sort Davidson, Alan
collection PubMed
description OBJECTIVE: To compare the experience with pinealoblastoma (PB) of the neuro-oncology services of the University of Cape Town to the WHO 2021 classification. METHODS: A retrospective analysis was performed on folders of patients diagnosed at Red Cross War Memorial Children’s Hospital and Groote Schuur Hospital from 2000-2022. Routine molecular testing is not available nor is testing for DICER mutations. Patients with PB associated with retinoblastoma (RB) were assumed to be Rb1-altered and were treated with ophthalmic local control and chemotherapy, and those without associated RB (assumed to be non-Rb1-altered) were mostly treated with surgery, chemotherapy and craniospinal radiotherapy. Convenience sampling was performed by age with respect to disease characteristics and outcome to try and disaggregate miRNA-processing-altered-1 and -2 from MYC/FOXR2-altered PB. RESULTS: Twenty-five patients were identified, 6 with Rb1-altered PB, aged 0.33-1.88 years (median 0.79) and 19 with non-Rb1-altered PB, aged 0.17-12.99 years (median 6.23). The whole cohort was balanced in terms of gender but there were slightly more girls (11) than boys (8) among the non-Rb1-altered PBs. One of these children was a 5-year-old boy with DICER syndrome who was identified through family screening. One Rb1-altered PB had metastatic disease outside the pineal gland. Among the non-Rb1-altered PBs 47% had metastases, 0% of those under 3 years, 40% of those aged 3-9 years and 80% of those older than 9 years. Estimated 5-year OS for the whole group was 49%, 50% for Rb1-altered PB and 49% for non-Rb1-altered PBs. OS by age among non-Rb1-altered PBs was 0% for 0-3 years, 90% for 3-9 years and 20% for those older than 9 years. CONCLUSION: DICER testing and molecular typing would be very useful in helping to stratify our non-Rb1-altered PBs, both for prognostication and to allow consideration of high-risk strategies. Multi-disciplinary treatment of PB in LMIC is essential.
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spelling pubmed-106165852023-11-01 PAEDIATRIC-11 EPIDEMIOLOGY OF PINEALOBLASTOMA IN CAPE TOWN, SOUTH AFRICA Davidson, Alan Ohonba, Efosa Parkes, Jeannette Pillay, Komala Figaji, Anthony Neurooncol Adv Final Category: Paediatric Oncology OBJECTIVE: To compare the experience with pinealoblastoma (PB) of the neuro-oncology services of the University of Cape Town to the WHO 2021 classification. METHODS: A retrospective analysis was performed on folders of patients diagnosed at Red Cross War Memorial Children’s Hospital and Groote Schuur Hospital from 2000-2022. Routine molecular testing is not available nor is testing for DICER mutations. Patients with PB associated with retinoblastoma (RB) were assumed to be Rb1-altered and were treated with ophthalmic local control and chemotherapy, and those without associated RB (assumed to be non-Rb1-altered) were mostly treated with surgery, chemotherapy and craniospinal radiotherapy. Convenience sampling was performed by age with respect to disease characteristics and outcome to try and disaggregate miRNA-processing-altered-1 and -2 from MYC/FOXR2-altered PB. RESULTS: Twenty-five patients were identified, 6 with Rb1-altered PB, aged 0.33-1.88 years (median 0.79) and 19 with non-Rb1-altered PB, aged 0.17-12.99 years (median 6.23). The whole cohort was balanced in terms of gender but there were slightly more girls (11) than boys (8) among the non-Rb1-altered PBs. One of these children was a 5-year-old boy with DICER syndrome who was identified through family screening. One Rb1-altered PB had metastatic disease outside the pineal gland. Among the non-Rb1-altered PBs 47% had metastases, 0% of those under 3 years, 40% of those aged 3-9 years and 80% of those older than 9 years. Estimated 5-year OS for the whole group was 49%, 50% for Rb1-altered PB and 49% for non-Rb1-altered PBs. OS by age among non-Rb1-altered PBs was 0% for 0-3 years, 90% for 3-9 years and 20% for those older than 9 years. CONCLUSION: DICER testing and molecular typing would be very useful in helping to stratify our non-Rb1-altered PBs, both for prognostication and to allow consideration of high-risk strategies. Multi-disciplinary treatment of PB in LMIC is essential. Oxford University Press 2023-10-31 /pmc/articles/PMC10616585/ http://dx.doi.org/10.1093/noajnl/vdad121.043 Text en © The Author(s) 2023. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Final Category: Paediatric Oncology
Davidson, Alan
Ohonba, Efosa
Parkes, Jeannette
Pillay, Komala
Figaji, Anthony
PAEDIATRIC-11 EPIDEMIOLOGY OF PINEALOBLASTOMA IN CAPE TOWN, SOUTH AFRICA
title PAEDIATRIC-11 EPIDEMIOLOGY OF PINEALOBLASTOMA IN CAPE TOWN, SOUTH AFRICA
title_full PAEDIATRIC-11 EPIDEMIOLOGY OF PINEALOBLASTOMA IN CAPE TOWN, SOUTH AFRICA
title_fullStr PAEDIATRIC-11 EPIDEMIOLOGY OF PINEALOBLASTOMA IN CAPE TOWN, SOUTH AFRICA
title_full_unstemmed PAEDIATRIC-11 EPIDEMIOLOGY OF PINEALOBLASTOMA IN CAPE TOWN, SOUTH AFRICA
title_short PAEDIATRIC-11 EPIDEMIOLOGY OF PINEALOBLASTOMA IN CAPE TOWN, SOUTH AFRICA
title_sort paediatric-11 epidemiology of pinealoblastoma in cape town, south africa
topic Final Category: Paediatric Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616585/
http://dx.doi.org/10.1093/noajnl/vdad121.043
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