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PAEDIATRIC-01 SURGICAL OUTCOME OF MEDULLOBLASTOMA IN ETHIOPIA

OBJECTIVE: Medulloblastoma is one of the commonest CNS[1] tumors in pediatric patients. This study tries to assess surgical treatment outcome and prognostic factors in patients diagnosed with medulloblastoma in Ethiopia, a LIC[2]. MATERIALS AND METHODS: Retrospective study involving twenty-seven pat...

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Autores principales: Akililu, Yemisirach Bizuneh, Woldemariam, Mersha Abebe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616605/
http://dx.doi.org/10.1093/noajnl/vdad121.038
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author Akililu, Yemisirach Bizuneh
Woldemariam, Mersha Abebe
author_facet Akililu, Yemisirach Bizuneh
Woldemariam, Mersha Abebe
author_sort Akililu, Yemisirach Bizuneh
collection PubMed
description OBJECTIVE: Medulloblastoma is one of the commonest CNS[1] tumors in pediatric patients. This study tries to assess surgical treatment outcome and prognostic factors in patients diagnosed with medulloblastoma in Ethiopia, a LIC[2]. MATERIALS AND METHODS: Retrospective study involving twenty-seven patients (21 pediatrics & 6 adults) who underwent surgery for medulloblastoma (January 1, 2010-April 30, 2018), at two neurosurgical centers. Structured questionnaire was used to collect patients’ data & surgical treatment outcome variables were assessed by suitable statistical tests. RESULTS: 1-year and 6-month survival probability were 29% and 41 % respectively with a median survival of 107 days (95% CI: 49,166). Median survival was 66 days (95% CI: 27,105), with 6 months and one-year survival rate of 24 % (p=0.031) for pediatric patients. Majority (61.90%) of pediatric deaths were in the first two months of surgery. Six months & one-year PFS[3] were around 83% and 44% respectively with median PFS of 9 months (95%CI: 7, 12). Younger age at presentation, postoperative open EVD[4], longer SICU[5] stay, lack of radiation treatment & postoperative complications were negative outcome predictors. CONCLUSION: Overall median and PFS of operated patients <15 years old is poor. Patients with negative outcome predictors have higher mortality& poor postoperative functional status. Standardization of treatment with surgery & CSI[6] ± chemotherapy yields longer survival rates in both pediatric and adult patients. [1] Central Nervous System [2] Low Income Country [3] Progression Free Survival [4] External Ventricular Drainage [5] Surgical Intensive Care Unit [6] Craniospinal Irradiation
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spelling pubmed-106166052023-11-01 PAEDIATRIC-01 SURGICAL OUTCOME OF MEDULLOBLASTOMA IN ETHIOPIA Akililu, Yemisirach Bizuneh Woldemariam, Mersha Abebe Neurooncol Adv Final Category: Paediatric Oncology OBJECTIVE: Medulloblastoma is one of the commonest CNS[1] tumors in pediatric patients. This study tries to assess surgical treatment outcome and prognostic factors in patients diagnosed with medulloblastoma in Ethiopia, a LIC[2]. MATERIALS AND METHODS: Retrospective study involving twenty-seven patients (21 pediatrics & 6 adults) who underwent surgery for medulloblastoma (January 1, 2010-April 30, 2018), at two neurosurgical centers. Structured questionnaire was used to collect patients’ data & surgical treatment outcome variables were assessed by suitable statistical tests. RESULTS: 1-year and 6-month survival probability were 29% and 41 % respectively with a median survival of 107 days (95% CI: 49,166). Median survival was 66 days (95% CI: 27,105), with 6 months and one-year survival rate of 24 % (p=0.031) for pediatric patients. Majority (61.90%) of pediatric deaths were in the first two months of surgery. Six months & one-year PFS[3] were around 83% and 44% respectively with median PFS of 9 months (95%CI: 7, 12). Younger age at presentation, postoperative open EVD[4], longer SICU[5] stay, lack of radiation treatment & postoperative complications were negative outcome predictors. CONCLUSION: Overall median and PFS of operated patients <15 years old is poor. Patients with negative outcome predictors have higher mortality& poor postoperative functional status. Standardization of treatment with surgery & CSI[6] ± chemotherapy yields longer survival rates in both pediatric and adult patients. [1] Central Nervous System [2] Low Income Country [3] Progression Free Survival [4] External Ventricular Drainage [5] Surgical Intensive Care Unit [6] Craniospinal Irradiation Oxford University Press 2023-10-31 /pmc/articles/PMC10616605/ http://dx.doi.org/10.1093/noajnl/vdad121.038 Text en © The Author(s) 2023. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Final Category: Paediatric Oncology
Akililu, Yemisirach Bizuneh
Woldemariam, Mersha Abebe
PAEDIATRIC-01 SURGICAL OUTCOME OF MEDULLOBLASTOMA IN ETHIOPIA
title PAEDIATRIC-01 SURGICAL OUTCOME OF MEDULLOBLASTOMA IN ETHIOPIA
title_full PAEDIATRIC-01 SURGICAL OUTCOME OF MEDULLOBLASTOMA IN ETHIOPIA
title_fullStr PAEDIATRIC-01 SURGICAL OUTCOME OF MEDULLOBLASTOMA IN ETHIOPIA
title_full_unstemmed PAEDIATRIC-01 SURGICAL OUTCOME OF MEDULLOBLASTOMA IN ETHIOPIA
title_short PAEDIATRIC-01 SURGICAL OUTCOME OF MEDULLOBLASTOMA IN ETHIOPIA
title_sort paediatric-01 surgical outcome of medulloblastoma in ethiopia
topic Final Category: Paediatric Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616605/
http://dx.doi.org/10.1093/noajnl/vdad121.038
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