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TRANSLATIONAL RESEARCH-02 THE KEYSTONE CYTOKINE, INTERLEUKIN-6, A KEY TARGET AND “ORGANIZING PRINCIPLE” FOR GLIOBLASTOMA THERAPY: A DECADE OF TRANSLATIONAL PROGRESS FROM GENOMICS TO THE LABORATORY AND TO A MULTICENTER CLINICAL TRIAL
Interleukin-6 (IL-6), the ‘keystone cytokine’, affects homeostatic processes, including innate and adaptive immunity, and is regarded as a prominent target for clinical intervention (Hunter, 2015). IL-6 is also a senescence-associated-gene (SAG), linked to cellular aging, the aging brain, and cancer...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616617/ http://dx.doi.org/10.1093/noajnl/vdad121.055 |