Lewis acid-promoted direct synthesis of isoxazole derivatives

Isoxazole derivatives were synthesized via a one-pot method utilizing 2-methylquinoline derivatives as template substrates, sodium nitrite as a nitrogen-oxygen source, and solely using aluminum trichloride as the additive. This approach circumvents the need for costly or highly toxic transition meta...

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Detalles Bibliográficos
Autores principales: Qiu, Dengxu, Jiang, Chenhui, Gao, Pan, Yuan, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2023
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616705/
https://www.ncbi.nlm.nih.gov/pubmed/37915558
http://dx.doi.org/10.3762/bjoc.19.113
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author Qiu, Dengxu
Jiang, Chenhui
Gao, Pan
Yuan, Yu
author_facet Qiu, Dengxu
Jiang, Chenhui
Gao, Pan
Yuan, Yu
author_sort Qiu, Dengxu
collection PubMed
description Isoxazole derivatives were synthesized via a one-pot method utilizing 2-methylquinoline derivatives as template substrates, sodium nitrite as a nitrogen-oxygen source, and solely using aluminum trichloride as the additive. This approach circumvents the need for costly or highly toxic transition metals and presents a novel pathway for the synthesis of isoxazole derivatives.
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spelling pubmed-106167052023-11-01 Lewis acid-promoted direct synthesis of isoxazole derivatives Qiu, Dengxu Jiang, Chenhui Gao, Pan Yuan, Yu Beilstein J Org Chem Full Research Paper Isoxazole derivatives were synthesized via a one-pot method utilizing 2-methylquinoline derivatives as template substrates, sodium nitrite as a nitrogen-oxygen source, and solely using aluminum trichloride as the additive. This approach circumvents the need for costly or highly toxic transition metals and presents a novel pathway for the synthesis of isoxazole derivatives. Beilstein-Institut 2023-10-16 /pmc/articles/PMC10616705/ /pubmed/37915558 http://dx.doi.org/10.3762/bjoc.19.113 Text en Copyright © 2023, Qiu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article licensed under the terms of the Beilstein-Institut Open Access License Agreement (https://www.beilstein-journals.org/bjoc/terms/terms), which is identical to the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ). The reuse of material under this license requires that the author(s), source and license are credited. Third-party material in this article could be subject to other licenses (typically indicated in the credit line), and in this case, users are required to obtain permission from the license holder to reuse the material.
spellingShingle Full Research Paper
Qiu, Dengxu
Jiang, Chenhui
Gao, Pan
Yuan, Yu
Lewis acid-promoted direct synthesis of isoxazole derivatives
title Lewis acid-promoted direct synthesis of isoxazole derivatives
title_full Lewis acid-promoted direct synthesis of isoxazole derivatives
title_fullStr Lewis acid-promoted direct synthesis of isoxazole derivatives
title_full_unstemmed Lewis acid-promoted direct synthesis of isoxazole derivatives
title_short Lewis acid-promoted direct synthesis of isoxazole derivatives
title_sort lewis acid-promoted direct synthesis of isoxazole derivatives
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616705/
https://www.ncbi.nlm.nih.gov/pubmed/37915558
http://dx.doi.org/10.3762/bjoc.19.113
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AT gaopan lewisacidpromoteddirectsynthesisofisoxazolederivatives
AT yuanyu lewisacidpromoteddirectsynthesisofisoxazolederivatives

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