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Case report: Successful treatment of refractory membranous nephropathy with telitacicept

Despite various treatment methods, the remission rate of membranous nephropathy remains limited. Refractory membranous nephropathy especially lacks effective treatment plans. Telitacicept achieves comprehensive inhibition of CD20-positive B cells, plasma cells, and T cells, thereby bringing new hope...

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Detalles Bibliográficos
Autores principales: Zhang, Lei, Jin, Hua, Wang, Dong, Wang, Yiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616774/
https://www.ncbi.nlm.nih.gov/pubmed/37915584
http://dx.doi.org/10.3389/fimmu.2023.1268929
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author Zhang, Lei
Jin, Hua
Wang, Dong
Wang, Yiping
author_facet Zhang, Lei
Jin, Hua
Wang, Dong
Wang, Yiping
author_sort Zhang, Lei
collection PubMed
description Despite various treatment methods, the remission rate of membranous nephropathy remains limited. Refractory membranous nephropathy especially lacks effective treatment plans. Telitacicept achieves comprehensive inhibition of CD20-positive B cells, plasma cells, and T cells, thereby bringing new hope to the treatment of membranous nephropathy and refractory membranous nephropathy. Here, we report a case of a 46-year-old man with membranous nephropathy. Although the combined treatment with glucocorticoid, tacrolimus, mycophenolate mofetil, cyclophosphamide, and rituximab was not successful, the patient achieved complete remission of urinary protein after glucocorticoid combined with telitacicept. This is the first report on the application of telitacicept in the treatment of membranous nephropathy, especially refractory membranous nephropathy. The application of telitacicept in the treatment of membranous nephropathy deserves further attention.
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spelling pubmed-106167742023-11-01 Case report: Successful treatment of refractory membranous nephropathy with telitacicept Zhang, Lei Jin, Hua Wang, Dong Wang, Yiping Front Immunol Immunology Despite various treatment methods, the remission rate of membranous nephropathy remains limited. Refractory membranous nephropathy especially lacks effective treatment plans. Telitacicept achieves comprehensive inhibition of CD20-positive B cells, plasma cells, and T cells, thereby bringing new hope to the treatment of membranous nephropathy and refractory membranous nephropathy. Here, we report a case of a 46-year-old man with membranous nephropathy. Although the combined treatment with glucocorticoid, tacrolimus, mycophenolate mofetil, cyclophosphamide, and rituximab was not successful, the patient achieved complete remission of urinary protein after glucocorticoid combined with telitacicept. This is the first report on the application of telitacicept in the treatment of membranous nephropathy, especially refractory membranous nephropathy. The application of telitacicept in the treatment of membranous nephropathy deserves further attention. Frontiers Media S.A. 2023-10-17 /pmc/articles/PMC10616774/ /pubmed/37915584 http://dx.doi.org/10.3389/fimmu.2023.1268929 Text en Copyright © 2023 Zhang, Jin, Wang and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhang, Lei
Jin, Hua
Wang, Dong
Wang, Yiping
Case report: Successful treatment of refractory membranous nephropathy with telitacicept
title Case report: Successful treatment of refractory membranous nephropathy with telitacicept
title_full Case report: Successful treatment of refractory membranous nephropathy with telitacicept
title_fullStr Case report: Successful treatment of refractory membranous nephropathy with telitacicept
title_full_unstemmed Case report: Successful treatment of refractory membranous nephropathy with telitacicept
title_short Case report: Successful treatment of refractory membranous nephropathy with telitacicept
title_sort case report: successful treatment of refractory membranous nephropathy with telitacicept
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616774/
https://www.ncbi.nlm.nih.gov/pubmed/37915584
http://dx.doi.org/10.3389/fimmu.2023.1268929
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