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Temperature-Sensitive Nanocarbon Hydrogel for Photothermal Therapy of Tumors

BACKGROUND: Intelligent hydrogels continue to encounter formidable obstacles in the field of cancer treatment. A wide variety of hydrogel materials have been designed for diverse purposes, but materials with satisfactory therapeutic effects are still urgently needed. METHODS: Here, we prepared an in...

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Autores principales: Tan, Wanlin, Chen, Sijie, Xu, Yan, Chen, Mingyu, Liao, Haiqin, Niu, Chengcheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616783/
https://www.ncbi.nlm.nih.gov/pubmed/37915748
http://dx.doi.org/10.2147/IJN.S429626
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author Tan, Wanlin
Chen, Sijie
Xu, Yan
Chen, Mingyu
Liao, Haiqin
Niu, Chengcheng
author_facet Tan, Wanlin
Chen, Sijie
Xu, Yan
Chen, Mingyu
Liao, Haiqin
Niu, Chengcheng
author_sort Tan, Wanlin
collection PubMed
description BACKGROUND: Intelligent hydrogels continue to encounter formidable obstacles in the field of cancer treatment. A wide variety of hydrogel materials have been designed for diverse purposes, but materials with satisfactory therapeutic effects are still urgently needed. METHODS: Here, we prepared an injectable hydrogel by means of physical crosslinking. Carbon nanoparticle suspension injection (CNSI), a sentinel lymph node imaging agent that has been widely used in the clinic, with sodium β-glycerophosphate (β-GP) were added to a temperature-sensitive chitosan (CS) hydrogel (CS/GP@CN) as an agent for photothermal therapy (PTT). After evaluating the rheological, morphological, and structural properties of the hydrogel, we used 4T1 mouse breast cancer cells and B16 melanoma cells to assess its in vitro properties. Then, we intratumorally injected the hydrogel into BALB/c tumor-bearing mice to assess the in vivo PTT effect, antitumor immune response and the number of lung metastases. RESULTS: Surprisingly, this nanocarbon hydrogel called CS/GP@CN hydrogel not only had good biocompatibility and a great PTT effect under 808nm laser irradiation but also facilitated the maturation of dendritic cells to stimulate the antitumor immune response and had an extraordinary antimetastatic effect in the lungs. DISCUSSION: Overall, this innovative temperature-sensitive nanocarbon hydrogel, which exists in a liquid state at room temperature and transforms to a gel at 37 °C, is an outstanding local delivery platform with tremendous PTT potential and broad clinical application prospects.
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spelling pubmed-106167832023-11-01 Temperature-Sensitive Nanocarbon Hydrogel for Photothermal Therapy of Tumors Tan, Wanlin Chen, Sijie Xu, Yan Chen, Mingyu Liao, Haiqin Niu, Chengcheng Int J Nanomedicine Original Research BACKGROUND: Intelligent hydrogels continue to encounter formidable obstacles in the field of cancer treatment. A wide variety of hydrogel materials have been designed for diverse purposes, but materials with satisfactory therapeutic effects are still urgently needed. METHODS: Here, we prepared an injectable hydrogel by means of physical crosslinking. Carbon nanoparticle suspension injection (CNSI), a sentinel lymph node imaging agent that has been widely used in the clinic, with sodium β-glycerophosphate (β-GP) were added to a temperature-sensitive chitosan (CS) hydrogel (CS/GP@CN) as an agent for photothermal therapy (PTT). After evaluating the rheological, morphological, and structural properties of the hydrogel, we used 4T1 mouse breast cancer cells and B16 melanoma cells to assess its in vitro properties. Then, we intratumorally injected the hydrogel into BALB/c tumor-bearing mice to assess the in vivo PTT effect, antitumor immune response and the number of lung metastases. RESULTS: Surprisingly, this nanocarbon hydrogel called CS/GP@CN hydrogel not only had good biocompatibility and a great PTT effect under 808nm laser irradiation but also facilitated the maturation of dendritic cells to stimulate the antitumor immune response and had an extraordinary antimetastatic effect in the lungs. DISCUSSION: Overall, this innovative temperature-sensitive nanocarbon hydrogel, which exists in a liquid state at room temperature and transforms to a gel at 37 °C, is an outstanding local delivery platform with tremendous PTT potential and broad clinical application prospects. Dove 2023-10-27 /pmc/articles/PMC10616783/ /pubmed/37915748 http://dx.doi.org/10.2147/IJN.S429626 Text en © 2023 Tan et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Tan, Wanlin
Chen, Sijie
Xu, Yan
Chen, Mingyu
Liao, Haiqin
Niu, Chengcheng
Temperature-Sensitive Nanocarbon Hydrogel for Photothermal Therapy of Tumors
title Temperature-Sensitive Nanocarbon Hydrogel for Photothermal Therapy of Tumors
title_full Temperature-Sensitive Nanocarbon Hydrogel for Photothermal Therapy of Tumors
title_fullStr Temperature-Sensitive Nanocarbon Hydrogel for Photothermal Therapy of Tumors
title_full_unstemmed Temperature-Sensitive Nanocarbon Hydrogel for Photothermal Therapy of Tumors
title_short Temperature-Sensitive Nanocarbon Hydrogel for Photothermal Therapy of Tumors
title_sort temperature-sensitive nanocarbon hydrogel for photothermal therapy of tumors
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616783/
https://www.ncbi.nlm.nih.gov/pubmed/37915748
http://dx.doi.org/10.2147/IJN.S429626
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